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Haploid genotype - cdc19-P1(P257L,T272I aa)

Genotype summary

Description
cdc19-P1(P257L,T272I aa)
Organism
Schizosaccharomyces pombe (fission yeast)

Allele summary

gene Product Allele name Description Type Expression
mcm2 (SPBC4.04c)MCM complex subunit Mcm2cdc19-P1P257L,T272Iamino_acid_mutationNot assayed or wild type

Annotation

Single locus phenotype

FYPO:0000608 - abnormal cell cycle arrest in mitotic M phase

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FYPO:0000848 - abnormal chromosome morphology during vegetative growth

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FYPO:0000444 - abnormal mitotic cell cycle arrest with replicated DNA

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FYPO:0001424 - abolished protein localization to nucleus during vegetative growth

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FYPO:0000470 - decreased mating type switching

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FYPO:0001276 - decreased MCM complex assembly

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FYPO:0001324 - decreased protein level during vegetative growth

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FYPO:0005773 - elongated mononucleate aseptate vegetative cell

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FYPO:0001386 - increased haploidization

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FYPO:0000473 - increased mitotic recombination

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FYPO:0000455 - increased number of double-strand break sites during vegetative growth

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FYPO:0000972 - increased number of Rad52 foci during vegetative growth

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FYPO:0000839 - inviable elongated mononucleate aseptate cell

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FYPO:0001387 - loss of viability at high temperature

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FYPO:0000963 - normal growth on hydroxyurea

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FYPO:0000478 - normal meiosis

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FYPO:0004474 - normal mitotic cell cycle DNA replication checkpoint

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FYPO:0002043 - normal premeiotic DNA replication

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FYPO:0002099 - normal protein phosphorylation during cellular response to hydroxyurea

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FYPO:0000943 - normal spore morphology

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FYPO:0000783 - protein mislocalized to cytoplasm during vegetative growth

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