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Haploid genotype - cdc45-3A(S275A,S322A,S397A aa)

Genotype summary

Description
cdc45-3A(S275A,S322A,S397A aa)
Organism
Schizosaccharomyces pombe (fission yeast)

Allele summary

gene Product Allele name Description Type Expression
cdc45 (SPAC17D4.02)DNA replication pre-initiation complex subunit Cdc45cdc45-3AS275A,S322A,S397Aamino_acid_mutationNot assayed or wild type

Annotation

Single locus phenotype

FYPO:0004550 - abolished protein phosphorylation during cellular response to hydroxyurea

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FYPO:0007811 - decreased CMG replicative helicase activity

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FYPO:0003923 - decreased rate of mitotic DNA replication elongation

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FYPO:0007255 - decreased replication fork processing

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FYPO:0000614 - increased duration of mitotic S phase

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FYPO:0007550 - increased number of Rad52 foci during cellular response to hydroxyurea

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FYPO:0007814 - increased rate of mitotic DNA replication elongation during cellular response to hydroxyurea

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FYPO:0005704 - loss of viability following cellular response to hydroxyurea

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FYPO:0006726 - normal CMG complex assembly

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FYPO:0007813 - normal growth on stavudine

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FYPO:0005236 - normal protein localization to chromatin at stalled replication fork

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FYPO:0000088 - sensitive to hydroxyurea

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