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Haploid genotype - cdc45-3D(S275D,S322D,S397D aa) cds1delta

Genotype summary

Description
cdc45-3D(S275D,S322D,S397D aa) cds1delta
Organism
Schizosaccharomyces pombe (fission yeast)

Allele summary

gene Product Allele name Description Type Expression
cdc45 (SPAC17D4.02)DNA replication pre-initiation complex subunit Cdc45cdc45-3DS275D,S322D,S397Damino_acid_mutationNot assayed or wild type
cds1 (SPCC18B5.11c)DNA replication checkpoint kinase Cds1cds1deltadeletiondeletionNull

Annotation

Multi-locus phenotype

FYPO:0006321 - decreased protein localization to chromatin at stalled replication fork

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FYPO:0003923 - decreased rate of mitotic DNA replication elongation

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FYPO:0007255 - decreased replication fork processing

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FYPO:0007550 - increased number of Rad52 foci during cellular response to hydroxyurea

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FYPO:0007814 - increased rate of mitotic DNA replication elongation during cellular response to hydroxyurea

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FYPO:0007813 - normal growth on stavudine

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FYPO:0005236 - normal protein localization to chromatin at stalled replication fork

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FYPO:0000088 - sensitive to hydroxyurea

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