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Haploid genotype - clr3+(wild type)[Overexpression] mcl1-101(P493S,L763F,A767V aa) sir2+(wild type)[Overexpression]

Genotype summary

Description
clr3+(wild type)[Overexpression] mcl1-101(P493S,L763F,A767V aa) sir2+(wild type)[Overexpression]
Organism
Schizosaccharomyces pombe (fission yeast)

Allele summary

gene Product Allele name Description Type Expression
clr3 (SPBC800.03)SHREC complex histone deacetylase (class II) subunit, Clr3clr3+wild typewild_typeOverexpression
mcl1 (SPAPB1E7.02c)DNA polymerase alpha accessory factor Mcl1mcl1-101P493S,L763F,A767Vamino_acid_mutationNot assayed or wild type
sir2 (SPBC16D10.07c)histone deacetylase, Sirtuin family, NAD-dependent Sir2sir2+wild typewild_typeOverexpression

Annotation

Multi-locus phenotype

FYPO:0003412 - decreased chromatin silencing at centromere outer repeat

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Genes:

FYPO:0000091 - sensitive to thiabendazole

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