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Haploid genotype - clr4-F449Y(aa)

Genotype summary

Description
clr4-F449Y(aa)
Organism
Schizosaccharomyces pombe (fission yeast)

Allele summary

gene Product Allele name Description Type Expression
clr4 (SPBC428.08c)histone lysine H3-K9 methyltransferase (Suv39) Clr4clr4-F449YF449Yamino_acid_mutationNot assayed or wild type

Annotation

Single locus phenotype

FYPO:0007376 - abolished epigenetic heterochromatin inheritance

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FYPO:0008368 - abolished histone H3-K9 trimethylation at centromere during vegetative growth

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FYPO:0006993 - decreased chromatin silencing at centromere otr1R

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FYPO:0003412 - decreased chromatin silencing at centromere outer repeat

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FYPO:0004604 - decreased chromatin silencing at subtelomere

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FYPO:0002355 - decreased histone H3-K9 dimethylation at silent mating-type cassette during vegetative growth

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FYPO:0004137 - decreased histone H3-K9 dimethylation at subtelomeric heterochromatin during vegetative growth

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FYPO:0005845 - decreased histone H3-K9 trimethylation at silent mating-type cassette during vegetative growth

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FYPO:0004577 - decreased histone H3-K9 trimethylation at subtelomeric heterochromatin during vegetative growth

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FYPO:0000882 - decreased histone H3-K9 trimethylation during vegetative growth

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FYPO:0002386 - decreased protein localization to pericentric heterochromatin at centromere outer repeat region

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FYPO:0000966 - increased histone H3-K14 acetylation at centromere outer repeat during vegetative growth

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FYPO:0010018 - increased histone H3-K36 trimethylation at centromere outer repeat during vegetative growth

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FYPO:0010013 - increased histone H3-K4 trimethylation at centromere outer repeat during vegetative growth

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FYPO:0000874 - increased histone H3-K9 dimethylation at centromere during vegetative growth

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FYPO:0000873 - increased histone H3-K9 dimethylation during vegetative growth

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FYPO:0007311 - increased histone H4-K16 acetylation at centromere outer repeat during vegetative growth

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FYPO:0004380 - increased protein localization to pericentric heterochromatin during vegetative growth

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FYPO:0000703 - normal protein-protein interaction

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