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Diploid genotype - clr4-F449Y(aa)/clr4-F449Y(aa)

Genotype summary

Description
clr4-F449Y(aa)/clr4-F449Y(aa)
Organism
Schizosaccharomyces pombe (fission yeast)

Allele summary

locus Product Allele name Description Type Expression
clr4 (SPBC428.08c)histone lysine H3-K9 methyltransferase (Suv39) Clr4clr4-F449YF449Yamino_acid_mutationNot assayed or wild type
clr4-F449YF449Yamino_acid_mutationNot assayed or wild type

Annotation

Single locus phenotype

FYPO:0005641 - abnormal chromosome segregation during meiosis I with premature sister kinetochore separation, lagging chromosomes, and normal chromosome separation

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FYPO:0008050 - abolished histone H3-K4 methylation during meiosis

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FYPO:0008038 - abolished histone H3-K4 trimethylation during mitosis

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FYPO:0005888 - decreased protein localization to centromeric chromatin, with protein mislocalized to nucleoplasm

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FYPO:0008048 - increased histone H3-K4 dimethylation at centromere during meiosis

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FYPO:0008052 - increased histone H3-K4 dimethylation during mitosis

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FYPO:0002150 - inviable spore population

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FYPO:0005634 - sister kinetochore dissociation in meiotic metaphase I with equational sister chromatid segregation in meiosis I

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