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Haploid genotype - clr4-IDR-Mut1(R85Q,K87Q,K94Q,R98Q,R101Q,R104Q aa)

Genotype summary

Description
clr4-IDR-Mut1(R85Q,K87Q,K94Q,R98Q,R101Q,R104Q aa)
Organism
Schizosaccharomyces pombe (fission yeast)

Allele summary

gene Product Allele name Description Type Expression
clr4 (SPBC428.08c)histone lysine H3-K9 methyltransferase (Suv39) Clr4clr4-IDR-Mut1R85Q,K87Q,K94Q,R98Q,R101Q,R104Qamino_acid_mutationNot assayed or wild type

Annotation

Single locus phenotype

FYPO:0002133 - abolished protein-RNA interaction

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FYPO:0006993 - decreased chromatin silencing at centromere otr1R

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FYPO:0002827 - decreased chromatin silencing at silent mating-type cassette

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FYPO:0005018 - decreased double-stranded DNA binding

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FYPO:0000888 - decreased histone H3-K9 dimethylation at centromere outer repeat during vegetative growth

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FYPO:0002355 - decreased histone H3-K9 dimethylation at silent mating-type cassette during vegetative growth

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FYPO:0004227 - decreased nucleosome binding

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FYPO:0003573 - decreased protein localization to heterochromatin at silent mating-type cassette

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FYPO:0002134 - decreased protein-RNA interaction

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FYPO:0004689 - increased cenH-derived RNA level

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FYPO:0010047 - increased histone methyltransferase activity

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FYPO:0004742 - normal chromatin silencing at centromere outer repeat

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FYPO:0001509 - normal protein localization to chromatin during vegetative growth

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FYPO:0010049 - normal protein localization to heterochromatin at silent mating-type cassette cenH region

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FYPO:0000703 - normal protein-protein interaction

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