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Haploid genotype - clr4-W31G(aa)

Genotype summary

Description
clr4-W31G(aa)
Organism
Schizosaccharomyces pombe (fission yeast)

Allele summary

gene Product Allele name Description Type Expression
clr4 (SPBC428.08c)histone lysine H3-K9 methyltransferase (Suv39) Clr4clr4-W31GW31Gamino_acid_mutationNot assayed or wild type

Annotation

Single locus phenotype

FYPO:0007376 - abolished epigenetic heterochromatin inheritance

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FYPO:0000705 - abolished protein-protein interaction

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FYPO:0002834 - decreased chromatin silencing at centromere

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FYPO:0002827 - decreased chromatin silencing at silent mating-type cassette

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FYPO:0002355 - decreased histone H3-K9 dimethylation at silent mating-type cassette during vegetative growth

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FYPO:0003096 - decreased histone H3-K9 methylation at centromere outer repeat during vegetative growth

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FYPO:0003571 - decreased histone H3-K9 methylation at silent mating-type cassette during vegetative growth

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FYPO:0000890 - decreased histone H3-K9 trimethylation at centromere outer repeat during vegetative growth

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FYPO:0005845 - decreased histone H3-K9 trimethylation at silent mating-type cassette during vegetative growth

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FYPO:0008195 - decreased histone H3-K9Me binding

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FYPO:0003151 - decreased protein level during cellular response to heat

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FYPO:0003573 - decreased protein localization to heterochromatin at silent mating-type cassette

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FYPO:0002386 - decreased protein localization to pericentric heterochromatin at centromere outer repeat region

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FYPO:0001740 - increased gross chromosomal rearrangement

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FYPO:0000887 - increased histone H3-K9 dimethylation at centromere outer repeat during vegetative growth

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FYPO:0002358 - normal histone H3-K9 dimethylation at silent mating-type cassette during vegetative growth

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FYPO:0006845 - normal histone methyltransferase activity (H3-K9 specific) activity

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FYPO:0008236 - normal siRNA loading onto RITS complex

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