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Haploid genotype - clr4delta dcr1delta

Genotype summary

Description
clr4delta dcr1delta
Organism
Schizosaccharomyces pombe (fission yeast)

Allele summary

gene Product Allele name Description Type Expression
clr4 (SPBC428.08c)histone lysine H3-K9 methyltransferase (Suv39) Clr4clr4deltadeletiondeletionNull
dcr1 (SPCC188.13c)dicerdcr1deltadeletiondeletionNull

Annotation

Multi-locus phenotype

FYPO:0004745 - abolished histone H3-K9 dimethylation at centromere outer repeat during vegetative growth

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FYPO:0003412 - decreased chromatin silencing at centromere outer repeat

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FYPO:0007642 - decreased histone H3-K9 dimethylation at rDNA during G0

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FYPO:0007639 - increased DNA damage at rDNA during G0

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FYPO:0004032 - increased protein localization to chromatin at rDNA

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FYPO:0006660 - loss of viability upon G0 to G1 transition

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FYPO:0007629 - normal viability during G0

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FYPO:0000091 - sensitive to thiabendazole

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