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Haploid genotype - clr4delta mlo3delta

Genotype summary

Description
clr4delta mlo3delta
Organism
Schizosaccharomyces pombe (fission yeast)

Allele summary

gene Product Allele name Description Type Expression
clr4 (SPBC428.08c)histone lysine H3-K9 methyltransferase (Suv39) Clr4clr4deltadeletiondeletionNull
mlo3 (SPBC1D7.04)RNA-binding protein Mlo3mlo3deltadeletiondeletionNull

Annotation

Multi-locus phenotype

FYPO:0005554 - abolished histone H3-K9 dimethylation at centromere inner repeat during vegetative growth

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FYPO:0004745 - abolished histone H3-K9 dimethylation at centromere outer repeat during vegetative growth

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FYPO:0006813 - abolished histone H3-K9 trimethylation at centromere inner repeat during vegetative growth

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FYPO:0005843 - abolished histone H3-K9 trimethylation at centromere outer repeat during vegetative growth

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FYPO:0001740 - increased gross chromosomal rearrangement

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FYPO:0006815 - increased histone H3-K14 acetylation at centromere inner repeat during vegetative growth

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FYPO:0000966 - increased histone H3-K14 acetylation at centromere outer repeat during vegetative growth

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FYPO:0006681 - increased histone H3-K9 acetylation at centromere inner repeat during vegetative growth

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FYPO:0006814 - increased histone H3-K9 acetylation at centromere outer repeat during vegetative growth

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FYPO:0001840 - increased minichromosome loss during vegetative growth

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FYPO:0004237 - increased protein localization to heterochromatin at centromere outer repeat region

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FYPO:0006992 - normal chromatin silencing at centromere otr1R

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FYPO:0000091 - sensitive to thiabendazole

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