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Haploid genotype - clr6-1(G269D aa)

Genotype summary

Description
clr6-1(G269D aa)
Organism
Schizosaccharomyces pombe (fission yeast)

Allele summary

gene Product Allele name Description Type Expression
clr6 (SPBC36.05c)histone deacetylase (class I) H3-K9 specific complex subunit Clr6clr6-1G269Damino_acid_mutationNot assayed or wild type

Annotation

Single locus phenotype

FYPO:0000141 - abnormal mitotic sister chromatid segregation

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FYPO:0000082 - decreased cell population growth at high temperature

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FYPO:0001407 - decreased cell population growth on glucose carbon source

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FYPO:0000250 - decreased cell population growth on proline nitrogen source

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FYPO:0003411 - decreased chromatin silencing at centromere inner repeat

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FYPO:0003412 - decreased chromatin silencing at centromere outer repeat

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FYPO:0003571 - decreased histone H3-K9 methylation at silent mating-type cassette during vegetative growth

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FYPO:0006321 - decreased protein localization to chromatin at stalled replication fork

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FYPO:0001128 - decreased septation index

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FYPO:0005545 - decreased Tf body formation

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FYPO:0007270 - decreased Tf body tethering to centromere

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FYPO:0001355 - decreased vegetative cell population growth

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FYPO:0002019 - elongated telomeres during vegetative growth

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FYPO:0003557 - increased antisense RNA level

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FYPO:0005315 - increased chromatin silencing at centromere central core

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FYPO:0003547 - increased DNA damage during vegetative growth

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FYPO:0000274 - increased duration of mitotic M phase

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FYPO:0005522 - increased forward centromeric outer repeat transcript level

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FYPO:0001740 - increased gross chromosomal rearrangement

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FYPO:0010012 - increased histone H2B-K33 acetylation during vegetative growth

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FYPO:0002363 - increased histone H3 acetylation during vegetative growth

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FYPO:0007307 - increased histone H3-K14 acetylation at centromere during vegetative growth

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FYPO:0005310 - increased histone H3-K14 acetylation during vegetative growth

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FYPO:0004238 - increased histone H3-K4 acetylation during vegetative growth

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FYPO:0005063 - increased histone H3-K4 methylation at mating type locus during vegetative growth

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FYPO:0000893 - increased histone H3-K9 acetylation at centromere during vegetative growth

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FYPO:0004690 - increased histone H3-K9 acetylation at silent mating-type cassette during vegetative growth

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FYPO:0000892 - increased histone H3-K9 acetylation during vegetative growth

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FYPO:0000887 - increased histone H3-K9 dimethylation at centromere outer repeat during vegetative growth

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FYPO:0006987 - increased histone H3-K9 dimethylation at silent mating-type cassette during vegetative growth

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FYPO:0006361 - increased histone H3-K9 dimethylation at subtelomeric heterochromatin during vegetative growth

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FYPO:0002365 - increased histone H4 acetylation during vegetative growth

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FYPO:0007306 - increased histone H4-K12 acetylation at centromere during vegetative growth

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FYPO:0007631 - increased histone H4-K12 acetylation during vegetative growth

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FYPO:0008174 - increased histone H4-K16 acetylation at silent mating-type cassette during vegetative growth

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FYPO:0007632 - increased histone H4-K16 acetylation during vegetative growth

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FYPO:0007305 - increased histone H4-K5 acetylation at centromere during vegetative growth

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FYPO:0008172 - increased histone H4-K5 acetylation at silent mating-type cassette during vegetative growth

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FYPO:0005309 - increased histone H4-K5 acetylation during vegetative growth

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FYPO:0005308 - increased histone H4-K8 acetylation during vegetative growth

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FYPO:0002172 - increased level of nitrogen starvation gene mRNA during vegetative growth

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FYPO:0001840 - increased minichromosome loss during vegetative growth

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FYPO:0002095 - increased protein phosphorylation during cellular response to DNA damage

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FYPO:0010016 - increased replication fork stalling during cellular response to DNA damage

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FYPO:0005523 - increased reverse centromeric outer repeat transcript level

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FYPO:0005917 - increased subtelomeric heterochromatin RNA level

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FYPO:0000594 - increased transposition

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FYPO:0002061 - inviable vegetative cell population

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FYPO:0000228 - lagging mitotic chromosomes

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FYPO:0002336 - normal chromatin silencing at silent mating-type cassette

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FYPO:0003555 - normal chromatin silencing at subtelomere

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FYPO:0000963 - normal growth on hydroxyurea

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FYPO:0002390 - normal mitotic sister chromatid cohesion

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FYPO:0000856 - normal nucleosome positioning

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FYPO:0001317 - normal RNA level during vegetative growth

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FYPO:0004325 - sensitive to 5-fluorouracil

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FYPO:0000095 - sensitive to bleomycin

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FYPO:0000085 - sensitive to camptothecin

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FYPO:0000088 - sensitive to hydroxyurea

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FYPO:0000089 - sensitive to methyl methanesulfonate

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FYPO:0000091 - sensitive to thiabendazole

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FYPO:0000268 - sensitive to UV during vegetative growth

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FYPO:0001234 - slow vegetative cell population growth

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FYPO:0001492 - viable elongated vegetative cell

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