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Haploid genotype - dis2-11(R245Q aa)

Genotype summary

Description
dis2-11(R245Q aa)
Organism
Schizosaccharomyces pombe (fission yeast)

Allele summary

gene Product Allele name Description Type Expression
dis2 (SPBC776.02c)serine/threonine protein phosphatase PP1 catalytic subunit Dis2dis2-11R245Qamino_acid_mutationNot assayed or wild type

Annotation

Single locus phenotype

FYPO:0007303 - abnormal cell cycle arrest in mitotic metaphase with condensed chromosomes

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FYPO:0004022 - abnormal cell cycle arrest in mitotic metaphase with long polar microtubules

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FYPO:0000671 - abnormal rDNA separation

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FYPO:0001946 - abolished mitotic sister chromatid separation

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FYPO:0001270 - complete but unequal mitotic sister chromatid segregation

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FYPO:0000080 - decreased cell population growth at low temperature

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FYPO:0002909 - decreased protein localization to chromatin during vegetative growth

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FYPO:0001757 - decreased protein phosphatase activity

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FYPO:0001840 - increased minichromosome loss during vegetative growth

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FYPO:0001862 - increased minichromosome loss upon segregation during meiotic cell cycle

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FYPO:0007534 - increased phosphorylation of RNA polymerase II C-terminal domain threonine 4 residues during vegetative growth

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FYPO:0006614 - increased termination of RNA polymerase II transcription

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FYPO:0002061 - inviable vegetative cell population

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FYPO:0003086 - normal chromatin binding

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FYPO:0001164 - normal growth on glucose carbon source

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FYPO:0000964 - normal growth on thiabendazole

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FYPO:0001761 - normal mitotic G1/S phase transition

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FYPO:0004422 - normal protein phosphorylation

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FYPO:0000097 - sensitive to caffeine during vegetative growth

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FYPO:0001491 - viable vegetative cell

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