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Haploid genotype - hht1delta hht2-S86A,S87A(S87A,S88A aa) hht3delta

Genotype summary

Description
hht1delta hht2-S86A,S87A(S87A,S88A aa) hht3delta
Organism
Schizosaccharomyces pombe (fission yeast)

Allele summary

gene Product Allele name Description Type Expression
hht1 (SPAC1834.04)histone H3 h3.1hht1deltadeletiondeletionNull
hht2 (SPBC8D2.04)histone H3 h3.2hht2-S86A,S87AS87A,S88Aamino_acid_mutationNot assayed or wild type
hht3 (SPBC1105.11c)histone H3 h3.3hht3deltadeletiondeletionNull

Annotation

Multi-locus phenotype

FYPO:0000082 - decreased cell population growth at high temperature

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FYPO:0001324 - decreased protein level during vegetative growth

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FYPO:0001117 - decreased RNA level during vegetative growth

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FYPO:0004982 - increased centromeric transcript level

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FYPO:0004324 - increased histone H4-K16 acetylation at centromere central core during vegetative growth

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FYPO:0000284 - large and small daughter nuclei, with unequal mitotic sister chromatid segregation

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FYPO:0001387 - loss of viability at high temperature

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FYPO:0004981 - normal cellular histone level

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FYPO:0001903 - normal septation index

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FYPO:0004983 - sensitive to vorinostat

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FYPO:0001234 - slow vegetative cell population growth

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