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Haploid genotype - hst4-4SA(S354A,S355A,S362A,S363A aa)

Genotype summary

Description
hst4-4SA(S354A,S355A,S362A,S363A aa)
Organism
Schizosaccharomyces pombe (fission yeast)

Allele summary

gene Product Allele name Description Type Expression
hst4 (SPAC1783.04c)histone deacetylase, Sirtuin family, NAD-dependent Hst4hst4-4SAS354A,S355A,S362A,S363Aamino_acid_mutationNot assayed or wild type

Annotation

Single locus phenotype

FYPO:0005268 - abnormal mitotic cell cycle regulation during cellular response to methyl methanesulfonate

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FYPO:0007879 - abolished protein degradation during cellular response to methyl methanesulfonate

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FYPO:0004660 - abolished protein phosphorylation during cellular response to methyl methanesulfonate

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FYPO:0000912 - abolished protein ubiquitination during vegetative growth

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FYPO:0004240 - decreased histone H3-K56 acetylation during vegetative growth

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FYPO:0002909 - decreased protein localization to chromatin during vegetative growth

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FYPO:0007255 - decreased replication fork processing

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FYPO:0001355 - decreased vegetative cell population growth

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FYPO:0007881 - increased duration of histone H2A phosphorylation during cellular response to methyl methanesulfonate

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FYPO:0000614 - increased duration of mitotic S phase

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FYPO:0004189 - increased protein level during cellular response to hydroxyurea

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FYPO:0001327 - increased protein level during vegetative growth

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FYPO:0007882 - normal protein kinase activity during cellular response to methyl methanesulfonate

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FYPO:0000088 - sensitive to hydroxyurea

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FYPO:0000089 - sensitive to methyl methanesulfonate

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