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Haploid genotype - hta1-S121A(S122A aa) hta2-S121A(S122A aa)

Genotype summary

Description
hta1-S121A(S122A aa) hta2-S121A(S122A aa)
Organism
Schizosaccharomyces pombe (fission yeast)

Allele summary

gene Product Allele name Description Type Expression
hta1 (SPCC622.08c)histone H2A alphahta1-S121AS122Aamino_acid_mutationNot assayed or wild type
hta2 (SPAC19G12.06c)histone H2A betahta2-S121AS122Aamino_acid_mutationNot assayed or wild type

Annotation

Multi-locus phenotype

FYPO:0001093 - abolished chromatin binding

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FYPO:0004318 - abolished mitotic spindle assembly checkpoint

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FYPO:0006455 - abolished protein localization to meiotic spindle during meiosis I

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FYPO:0006456 - abolished protein localization to meiotic spindle during meiosis II

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FYPO:0005396 - abolished protein localization to subtelomeric heterochromatin

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FYPO:0002033 - abolished protein phosphorylation during vegetative growth

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FYPO:0006260 - abolished subtelomeric chromatin knob formation

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FYPO:0006423 - decreased meiotic sister chromatid cohesion at centromere during meiosis I

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FYPO:0000450 - decreased protein localization to centromere during vegetative growth

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FYPO:0002825 - decreased protein localization to mitotic spindle

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FYPO:0006263 - increased histone H3-K36 trimethylation during vegetative growth

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FYPO:0005225 - increased histone H3-K4 dimethylation during vegetative growth

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FYPO:0005917 - increased subtelomeric heterochromatin RNA level

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FYPO:0000228 - lagging mitotic chromosomes

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FYPO:0001164 - normal growth on glucose carbon source

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FYPO:0000091 - sensitive to thiabendazole

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FYPO:0003182 - sister chromatid nondisjunction at meiosis II

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FYPO:0005634 - sister kinetochore dissociation in meiotic metaphase I with equational sister chromatid segregation in meiosis I

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