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Haploid genotype - its3-1(G281D aa)

Genotype summary

Description
its3-1(G281D aa)
Organism
Schizosaccharomyces pombe (fission yeast)

Allele summary

gene Product Allele name Description Type Expression
its3 (SPAC19G12.14)1-phosphatidylinositol-4-phosphate 5-kinase Its3its3-1G281Damino_acid_mutationNot assayed or wild type

Annotation

Single locus phenotype

FYPO:0000790 - abnormal actin cortical patch organization

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FYPO:0008042 - abolished establishment or maintenance of actin cytoskeleton polarity during vegetative growth

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FYPO:0001880 - abolished protein localization to cell division site

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FYPO:0001585 - abolished protein localization to cell tip during vegetative growth

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FYPO:0002128 - abolished protein localization to plasma membrane, with protein mislocalized to cytoplasm, during vegetative growth

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FYPO:0005289 - actomyosin contractile ring sliding

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FYPO:0008039 - decreased 1-phosphatidylinositol-4-phosphate 5-kinase activity

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FYPO:0000082 - decreased cell population growth at high temperature

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FYPO:0006625 - decreased phosphatidylinositol-4,5-bisphosphate level in plasma membrane

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FYPO:0006628 - decreased phosphatidylinositol-4-phosphate level in plasma membrane

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FYPO:0000929 - decreased protein localization to cell cortex during vegetative growth

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FYPO:0002869 - decreased protein localization to cell division site

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FYPO:0006221 - decreased protein localization to cell division site, with protein mislocalized to cytoplasm

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FYPO:0001586 - decreased protein localization to cell tip during vegetative growth

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FYPO:0003208 - decreased protein localization to cell tip, with protein distributed in plasma membrane or cortex

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FYPO:0003771 - decreased protein localization to plasma membrane of cell tip during vegetative growth

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FYPO:0004780 - decreased protein localization to plasma membrane, with protein mislocalized to cytoplasm, during vegetative growth

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FYPO:0001355 - decreased vegetative cell population growth

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FYPO:0000994 - increased cellular phosphatidylinositol-4-phosphate level

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FYPO:0006626 - increased phosphatidylinositol-4,5-bisphosphate level in plasma membrane

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FYPO:0000650 - increased septation index

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FYPO:0001406 - increased septum thickness

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FYPO:0002061 - inviable vegetative cell population

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FYPO:0000339 - mislocalized septum during vegetative growth

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FYPO:0002559 - normal protein localization to actomyosin contractile ring

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FYPO:0002442 - normal protein localization to cell division site

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FYPO:0001587 - normal protein localization to cell tip during vegetative growth

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FYPO:0000086 - sensitive to tacrolimus

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