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Haploid genotype - lsd1-ao(K603A,K604A aa) lsd2-ao(K823A,K824A aa)

Genotype summary

Description
lsd1-ao(K603A,K604A aa) lsd2-ao(K823A,K824A aa)
Organism
Schizosaccharomyces pombe (fission yeast)

Allele summary

gene Product Allele name Description Type Expression
lsd1 (SPBC146.09c)histone demethylase SWIRM1lsd1-aoK603A,K604Aamino_acid_mutationNot assayed or wild type
lsd2 (SPAC23E2.02)histone demethylase SWIRM2lsd2-aoK823A,K824Aamino_acid_mutationNot assayed or wild type

Annotation

Multi-locus phenotype

FYPO:0007478 - decreased epigenetic heterochromatin inheritance

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FYPO:0003081 - decreased genetic imprinting at mating-type locus

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FYPO:0003085 - decreased replication fork arrest at mating-type locus

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FYPO:0001117 - decreased RNA level during vegetative growth

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FYPO:0005225 - increased histone H3-K4 dimethylation during vegetative growth

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FYPO:0000887 - increased histone H3-K9 dimethylation at centromere outer repeat during vegetative growth

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FYPO:0006987 - increased histone H3-K9 dimethylation at silent mating-type cassette during vegetative growth

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FYPO:0006361 - increased histone H3-K9 dimethylation at subtelomeric heterochromatin during vegetative growth

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FYPO:0001387 - loss of viability at high temperature

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FYPO:0002336 - normal chromatin silencing at silent mating-type cassette

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FYPO:0001164 - normal growth on glucose carbon source

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FYPO:0000964 - normal growth on thiabendazole

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FYPO:0001357 - normal vegetative cell population growth

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