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Haploid genotype - mal2-1(E277K aa)

Genotype summary

Description
mal2-1(E277K aa)
Organism
Schizosaccharomyces pombe (fission yeast)

Allele summary

gene Product Allele name Description Type Expression
mal2 (SPAC25B8.14)CENP-O ortholog Mal2mal2-1E277Kamino_acid_mutationNot assayed or wild type

Annotation

Single locus phenotype

FYPO:0004308 - abnormal CENP-A containing chromatin organization

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FYPO:0000141 - abnormal mitotic sister chromatid segregation

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FYPO:0001269 - abolished protein localization to kinetochore during vegetative growth

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FYPO:0001270 - complete but unequal mitotic sister chromatid segregation

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FYPO:0000082 - decreased cell population growth at high temperature

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FYPO:0003217 - decreased chromatin silencing at centromere central core

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FYPO:0001840 - increased minichromosome loss during vegetative growth

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FYPO:0001490 - inviable elongated vegetative cell

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FYPO:0002414 - inviable swollen vegetative cell

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FYPO:0002061 - inviable vegetative cell population

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FYPO:0004307 - long mitotic spindle during metaphase

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FYPO:0001387 - loss of viability at high temperature

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FYPO:0000324 - mitotic metaphase/anaphase transition delay

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FYPO:0001273 - mitotic spindle elongation with incomplete, unequal mitotic sister chromatid segregation and unseparated DNA

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FYPO:0001976 - normal cytoplasmic microtubules during vegetative growth

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FYPO:0000963 - normal growth on hydroxyurea

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FYPO:0001975 - normal growth on nocodazole

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FYPO:0002390 - normal mitotic sister chromatid cohesion

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FYPO:0001905 - normal mitotic spindle microtubules

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FYPO:0002901 - normal protein localization to kinetochore during vegetative growth

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FYPO:0001420 - normal vegetative cell population growth rate

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FYPO:0000094 - sensitive to benomyl

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FYPO:0000091 - sensitive to thiabendazole

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FYPO:0003241 - unequal mitotic sister chromatid segregation

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