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Haploid genotype - mcl1-101(P493S,L763F,A767V aa)

Genotype summary

Description
mcl1-101(P493S,L763F,A767V aa)
Organism
Schizosaccharomyces pombe (fission yeast)

Allele summary

gene Product Allele name Description Type Expression
mcl1 (SPAPB1E7.02c)DNA polymerase alpha accessory factor Mcl1mcl1-101P493S,L763F,A767Vamino_acid_mutationNot assayed or wild type

Annotation

Single locus phenotype

FYPO:0004308 - abnormal CENP-A containing chromatin organization

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FYPO:0003217 - decreased chromatin silencing at centromere central core

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FYPO:0003412 - decreased chromatin silencing at centromere outer repeat

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FYPO:0004313 - decreased protein localization to CENP-A containing chromatin

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FYPO:0004322 - decreased spatial extent of CENP-A containing chromatin assembly

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FYPO:0001355 - decreased vegetative cell population growth

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FYPO:0007314 - increased histone H4-K12 acetylation at centromere central core during vegetative growth

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FYPO:0004324 - increased histone H4-K16 acetylation at centromere central core during vegetative growth

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FYPO:0007312 - increased histone H4-K5 acetylation at centromere central core during vegetative growth

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FYPO:0007313 - increased histone H4-K8 acetylation at centromere central core during vegetative growth

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FYPO:0000839 - inviable elongated mononucleate aseptate cell

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FYPO:0001357 - normal vegetative cell population growth

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FYPO:0000095 - sensitive to bleomycin

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FYPO:0000088 - sensitive to hydroxyurea

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FYPO:0000089 - sensitive to methyl methanesulfonate

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FYPO:0000091 - sensitive to thiabendazole

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FYPO:0000268 - sensitive to UV during vegetative growth

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