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Haploid genotype - mis18-262(G117D aa)

Genotype summary

Description
mis18-262(G117D aa)
Organism
Schizosaccharomyces pombe (fission yeast)

Allele summary

gene Product Allele name Description Type Expression
mis18 (SPCC970.12)kinetochore protein Mis18mis18-262G117Damino_acid_mutationNot assayed or wild type

Annotation

Single locus phenotype

FYPO:0000141 - abnormal mitotic sister chromatid segregation

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FYPO:0003786 - abolished protein localization to centromere central core during vegetative growth

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FYPO:0000634 - abolished protein localization to centromere during vegetative growth

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FYPO:0001269 - abolished protein localization to kinetochore during vegetative growth

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FYPO:0003740 - decreased CENP-A containing chromatin assembly

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FYPO:0006818 - decreased protein localization to chromatin at centromere outer repeat

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FYPO:0002902 - decreased protein localization to kinetochore during vegetative growth

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FYPO:0003415 - increased histone H4 acetylation at centromere central core during vegetative growth

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FYPO:0000451 - increased protein localization to centromere during vegetative growth

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FYPO:0002061 - inviable vegetative cell population

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FYPO:0000284 - large and small daughter nuclei, with unequal mitotic sister chromatid segregation

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FYPO:0001387 - loss of viability at high temperature

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FYPO:0002574 - normal protein localization to centromere during vegetative growth

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FYPO:0002901 - normal protein localization to kinetochore during vegetative growth

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FYPO:0001357 - normal vegetative cell population growth

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