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Haploid genotype - mis6-302(G135E aa)

Genotype summary

Description
mis6-302(G135E aa)
Organism
Schizosaccharomyces pombe (fission yeast)

Allele summary

gene Product Allele name Description Type Expression
mis6 (SPAC1687.20c)CENP-I ortholog, inner centromere connector Mis6mis6-302G135Eamino_acid_mutationNot assayed or wild type

Annotation

Single locus phenotype

FYPO:0004308 - abnormal CENP-A containing chromatin organization

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FYPO:0001779 - abnormal centromere clustering at nuclear periphery during vegetative growth

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FYPO:0000640 - abnormal chromatin silencing at centromere central core

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FYPO:0000141 - abnormal mitotic sister chromatid segregation

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FYPO:0001268 - abnormal protein localization to kinetochore during vegetative growth

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FYPO:0004481 - abolished cell population growth at high temperature

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FYPO:0004318 - abolished mitotic spindle assembly checkpoint

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FYPO:0006174 - abolished mitotic spindle elongation during anaphase B

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FYPO:0003786 - abolished protein localization to centromere central core during vegetative growth

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FYPO:0000634 - abolished protein localization to centromere during vegetative growth

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FYPO:0001269 - abolished protein localization to kinetochore during vegetative growth

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FYPO:0000082 - decreased cell population growth at high temperature

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FYPO:0003740 - decreased CENP-A containing chromatin assembly

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FYPO:0003217 - decreased chromatin silencing at centromere central core

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FYPO:0004313 - decreased protein localization to CENP-A containing chromatin

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FYPO:0004904 - decreased protein localization to centromere central core during vegetative growth

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FYPO:0002902 - decreased protein localization to kinetochore during vegetative growth

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FYPO:0004322 - decreased spatial extent of CENP-A containing chromatin assembly

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FYPO:0001355 - decreased vegetative cell population growth

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FYPO:0002639 - increased interkinetochore distance before mitotic anaphase

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FYPO:0000786 - increased plasmid loss

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FYPO:0001489 - inviable vegetative cell

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FYPO:0002061 - inviable vegetative cell population

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FYPO:0000284 - large and small daughter nuclei, with unequal mitotic sister chromatid segregation

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FYPO:0006190 - long mitotic spindle during anaphase A

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FYPO:0003787 - long mitotic spindle microtubules protruding beyond spindle pole body

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FYPO:0001387 - loss of viability at high temperature

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FYPO:0006172 - mitotic spindle collapse without elongation during anaphase B

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FYPO:0000964 - normal growth on thiabendazole

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FYPO:0002574 - normal protein localization to centromere during vegetative growth

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FYPO:0002901 - normal protein localization to kinetochore during vegetative growth

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FYPO:0005216 - normal protein localization to mitotic spindle pole body during metaphase

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FYPO:0001357 - normal vegetative cell population growth

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FYPO:0000732 - short bipolar mitotic spindle

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FYPO:0003241 - unequal mitotic sister chromatid segregation

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