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Haploid genotype - mre11-H134S(aa)

Genotype summary

Description
mre11-H134S(aa)
Organism
Schizosaccharomyces pombe (fission yeast)

Allele summary

gene Product Allele name Description Type Expression
mre11 (SPAC13C5.07)Mre11 nucleasemre11-H134SH134Samino_acid_mutationNot assayed or wild type

Annotation

Single locus phenotype

FYPO:0000006 - abnormal mitotic DNA damage checkpoint

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FYPO:0000913 - abnormal sporulation resulting in formation of ascus containing non-uniform spores

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FYPO:0003164 - abolished nuclease activity

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FYPO:0001407 - decreased cell population growth on glucose carbon source

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FYPO:0004287 - decreased double-strand break repair via nonhomologous end joining

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FYPO:0002474 - decreased protein localization to double-strand break site

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FYPO:0002897 - decreased protein phosphorylation during cellular response to DNA damage

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FYPO:0002470 - decreased protein phosphorylation during cellular response to ionizing radiation

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FYPO:0004261 - decreased protein phosphorylation during mitotic G2 phase during cellular response to ionizing radiation

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FYPO:0000581 - decreased spore germination frequency

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FYPO:0000972 - increased number of Rad52 foci during vegetative growth

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FYPO:0002475 - increased protein localization to double-strand break site

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FYPO:0004286 - normal double-strand break repair via nonhomologous end joining

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FYPO:0002554 - normal protein localization to double-strand break site

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FYPO:0000703 - normal protein-protein interaction

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FYPO:0000085 - sensitive to camptothecin

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FYPO:0000088 - sensitive to hydroxyurea

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FYPO:0000267 - sensitive to ionizing radiation during vegetative growth

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FYPO:0000089 - sensitive to methyl methanesulfonate

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FYPO:0000268 - sensitive to UV during vegetative growth

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FYPO:0001492 - viable elongated vegetative cell

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