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Haploid genotype - pfh1+(wild type)[Knockdown]

Genotype summary

Description
pfh1+(wild type)[Knockdown]
Organism
Schizosaccharomyces pombe (fission yeast)

Allele summary

gene Product Allele name Description Type Expression
pfh1 (SPBC887.14c)mitochondrial 5' to 3' DNA helicase Pif1/Pfh1 OR nuclear 5' to 3' DNA helicase Pif1/Pfh1pfh1+wild typewild_typeKnockdown

Annotation

Single locus phenotype

FYPO:0003925 - decreased rate of mitotic DNA replication elongation at highly transcribed RNA polymerase II genes

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FYPO:0003924 - increased DNA damage at stalled replication fork

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FYPO:0005769 - increased histone H2A phosphorylation at G4 motif during vegetative growth

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FYPO:0005770 - increased histone H2A phosphorylation at highly transcribed RNA polymerase II genes during vegetative growth

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FYPO:0005771 - increased histone H2A phosphorylation at nucleosome-depleted regions during vegetative growth

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FYPO:0002604 - increased histone H2A phosphorylation at rDNA during vegetative growth

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FYPO:0005772 - increased histone H2A phosphorylation at tRNA genes during vegetative growth

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FYPO:0003926 - increased number of converged replication forks

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FYPO:0003920 - increased replication fork arrest at mating-type locus

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FYPO:0003921 - increased replication fork arrest at rDNA repeats

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FYPO:0003922 - increased replication fork arrest at tRNA locus

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FYPO:0005764 - increased replication fork pausing at G4 motif

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FYPO:0005765 - increased replication fork pausing at highly transcribed RNA polymerase II genes

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FYPO:0005766 - increased replication fork pausing at nucleosome-depleted regions

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FYPO:0005768 - increased replication fork pausing at rDNA

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FYPO:0005767 - increased replication fork pausing at tRNA genes

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FYPO:0001234 - slow vegetative cell population growth

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