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Haploid genotype - pku70delta

Genotype summary

Description
pku70delta
Organism
Schizosaccharomyces pombe (fission yeast)

Allele summary

gene Product Allele name Description Type Expression
pku70 (SPCC126.02c)Ku70 (human XRCC6 ortholog) Pku70pku70deltadeletiondeletionNull

Annotation

Single locus phenotype

FYPO:0000122 - abnormal telomere maintenance during vegetative growth

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FYPO:0005459 - abolished double-strand break repair via nonhomologous end joining

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FYPO:0003928 - altered double-strand break repair junction in presence of persistent double-strand breaks

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FYPO:0003660 - decreased double-strand break repair during vegetative growth

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FYPO:0004287 - decreased double-strand break repair via nonhomologous end joining

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FYPO:0005370 - decreased fidelity of double-strand break repair via nonhomologous end joining

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FYPO:0003913 - decreased minichromosome loss during vegetative growth

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FYPO:0004516 - decreased number of Rad52 foci during vegetative growth

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FYPO:0003927 - decreased population viability in presence of persistent double-strand breaks

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FYPO:0006321 - decreased protein localization to chromatin at stalled replication fork

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FYPO:0007532 - decreased replication fork colocalization with nuclear pore complex

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FYPO:0000581 - decreased spore germination frequency

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FYPO:0005545 - decreased Tf body formation

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FYPO:0007270 - decreased Tf body tethering to centromere

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FYPO:0004003 - delayed onset of replication fork processing

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FYPO:0009094 - increased cell population growth on lysine and proline nitrogen source

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FYPO:0009072 - increased cell population growth on lysine nitrogen source

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FYPO:0005372 - increased circular minichromosome loss during vegetative growth

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FYPO:0004251 - increased DNA resection during replication fork processing

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FYPO:0001740 - increased gross chromosomal rearrangement

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FYPO:0005371 - increased linear minichromosome loss during vegetative growth

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FYPO:0002573 - increased number of Ssb1 foci

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FYPO:0005402 - increased telomeric 3' overhang length during vegetative growth

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FYPO:0004557 - increased vegetative cell population growth

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FYPO:0006518 - loss of viability in G0

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FYPO:0000245 - loss of viability in stationary phase

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FYPO:0003118 - normal cellular reactive oxygen species level during vegetative growth

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FYPO:0001870 - normal centromere clustering at nuclear periphery during vegetative growth

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FYPO:0002335 - normal chromatin silencing

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FYPO:0003555 - normal chromatin silencing at subtelomere

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FYPO:0005398 - normal frequency of double-strand break repair via homologous recombination

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FYPO:0007553 - normal G1 to G0 transition

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FYPO:0004229 - normal growth during cellular response to ionizing radiation

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FYPO:0000969 - normal growth during cellular response to UV

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FYPO:0003906 - normal growth on bleomycin

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FYPO:0001690 - normal growth on camptothecin

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FYPO:0000963 - normal growth on hydroxyurea

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FYPO:0000957 - normal growth on methyl methanesulfonate

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FYPO:0003183 - normal growth on phleomycin

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FYPO:0007269 - normal interphase mitotic telomere clustering during vegetative growth

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FYPO:0007328 - normal number of Rad52 foci during vegetative growth

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FYPO:0007711 - normal number of Ssb1 foci

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FYPO:0002887 - normal protein localization to telomere during vegetative growth

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FYPO:0005614 - normal protein phosphorylation during cellular response to bleomycin

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FYPO:0007254 - normal replication fork processing

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FYPO:0002687 - normal telomere length during vegetative growth

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FYPO:0001357 - normal vegetative cell population growth

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FYPO:0001420 - normal vegetative cell population growth rate

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FYPO:0000764 - resistance to cycloheximide

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FYPO:0009038 - resistance to egtazic acid

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FYPO:0009087 - resistance to magnesium chloride and sodium dodecyl sulfate

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FYPO:0003383 - resistance to tert-butyl hydroperoxide

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FYPO:0000085 - sensitive to camptothecin

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FYPO:0004868 - sensitive to ionizing radiation during mitotic G1 phase

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FYPO:0001719 - sensitive to lithium

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FYPO:0009086 - sensitive to lithium chloride and sodium dodecyl sulfate

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FYPO:0000089 - sensitive to methyl methanesulfonate

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FYPO:0007924 - sensitive to potassium chloride and sodium dodecyl sulfate

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FYPO:0002239 - shortened telomeres during vegetative growth

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FYPO:0003929 - spores sensitive to ionizing radiation

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FYPO:0003106 - stable shortened telomeres during vegetative growth

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FYPO:0002060 - viable vegetative cell population

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FYPO:0002177 - viable vegetative cell with normal cell morphology

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