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Haploid genotype - pol1-AID[Knockdown] spp2-AID[Knockdown]

Genotype summary

Description
pol1-AID[Knockdown] spp2-AID[Knockdown]
Organism
Schizosaccharomyces pombe (fission yeast)

Allele summary

gene Product Allele name Description Type Expression
pol1 (SPAC3H5.06c)DNA polymerase alpha catalytic subunitpol1-AIDpol1-AIDfusion_or_chimeraKnockdown
spp2 (SPBC17D11.06)DNA primase large subunit Spp2spp2-AIDspp2-AIDfusion_or_chimeraKnockdown

Annotation

Multi-locus phenotype

FYPO:0001430 - abnormal mitotic cell cycle arrest with unreplicated DNA

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FYPO:0006728 - abolished mitotic DNA replication initiation

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FYPO:0005095 - abolished protein localization to chromatin at replication origin

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FYPO:0006731 - decreased CMG complex progression from replication origin

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FYPO:0006729 - decreased protein localization to chromatin distal to replication origin

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FYPO:0004962 - normal protein localization to chromatin at replication origin

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