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Haploid genotype - rdp1-D903A(aa)

Genotype summary

Description
rdp1-D903A(aa)
Organism
Schizosaccharomyces pombe (fission yeast)

Allele summary

gene Product Allele name Description Type Expression
rdp1 (SPAC6F12.09)RNA-directed RNA polymerase (RDRC) Rdp1rdp1-D903AD903Aamino_acid_mutationNot assayed or wild type

Annotation

Single locus phenotype

FYPO:0008009 - abnormal interphase mitotic telomere clustering during vegetative growth

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FYPO:0007334 - abolished chromatin silencing at centromere outer repeat

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FYPO:0008011 - abolished siRNA loading onto RITS complex

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FYPO:0003096 - decreased histone H3-K9 methylation at centromere outer repeat during vegetative growth

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FYPO:0003573 - decreased protein localization to heterochromatin at silent mating-type cassette

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FYPO:0002386 - decreased protein localization to pericentric heterochromatin at centromere outer repeat region

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FYPO:0008010 - decreased RNA-dependent RNA polymerase

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FYPO:0000228 - lagging mitotic chromosomes

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FYPO:0004083 - normal protein level

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FYPO:0004974 - normal telomere localization during mitotic interphase

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FYPO:0000091 - sensitive to thiabendazole

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