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Haploid genotype - set2delta

Genotype summary

Description
set2delta
Organism
Schizosaccharomyces pombe (fission yeast)

Allele summary

gene Product Allele name Description Type Expression
set2 (SPAC29B12.02c)histone lysine H3-K36 methyltransferase Set2set2deltadeletiondeletionNull

Annotation

Single locus phenotype

FYPO:0001352 - abnormal chromatin organization during vegetative growth

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FYPO:0007472 - abnormal histone exchange

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FYPO:0006403 - abolished histone H3-K36 dimethylation at promoter during vegetative growth

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FYPO:0002919 - abolished histone H3-K36 methylation during vegetative growth

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FYPO:0006402 - abolished histone H3-K36 trimethylation at promoter during vegetative growth

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FYPO:0006401 - decreased cellular dNTP level

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FYPO:0004604 - decreased chromatin silencing at subtelomere

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FYPO:0010055 - decreased histone H2A-S121 phosphorylation at subtelomere during vegetative growth

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FYPO:0006857 - decreased histone H3-K37 methylation

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FYPO:0000470 - decreased mating type switching

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FYPO:0004193 - decreased protein level during mitotic S phase

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FYPO:0005314 - decreased protein localization to chromatin at MCB promoters during vegetative growth

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FYPO:0010051 - decreased protein localization to subtelomeric chromatin knob during vegetative growth

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FYPO:0002387 - decreased protein localization to subtelomeric heterochromatin during vegetative growth

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FYPO:0002975 - decreased RNA level during cellular response to hydroxyurea

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FYPO:0001117 - decreased RNA level during vegetative growth

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FYPO:0005528 - decreased subtelomeric chromatin knob formation

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FYPO:0001355 - decreased vegetative cell population growth

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FYPO:0003557 - increased antisense RNA level

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FYPO:0002913 - increased antisense RNA transcription

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FYPO:0000220 - increased centromeric outer repeat transcript level

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FYPO:0000614 - increased duration of mitotic S phase

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FYPO:0005518 - increased histone H3-K14 acetylation at protein coding gene during vegetative growth

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FYPO:0005310 - increased histone H3-K14 acetylation during vegetative growth

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FYPO:0008219 - increased histone H3-K56 acetylation in transcribed regions during mitotic G2/M phase

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FYPO:0004347 - increased histone H3-K9 acetylation at protein coding gene during vegetative growth

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FYPO:0000892 - increased histone H3-K9 acetylation during vegetative growth

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FYPO:0010053 - increased histone H4-K12 acetylation at subtelomeric chromatin knob during vegetative growth

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FYPO:0008220 - increased histone H4-K20 monomethylation in transcribed regions during mitotic G2/M phase

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FYPO:0010052 - increased histone H4-K5 acetylation at subtelomeric chromatin knob during vegetative growth

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FYPO:0006400 - increased mitotic DNA replication initiation from inefficient origin

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FYPO:0005917 - increased subtelomeric heterochromatin RNA level

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FYPO:0006518 - loss of viability in G0

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FYPO:0000245 - loss of viability in stationary phase

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FYPO:0007553 - normal G1 to G0 transition

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FYPO:0008221 - normal histone H3-K56 acetylation during mitotic G2/M phase

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FYPO:0008222 - normal histone H4-K20 monomethylation during mitotic G2/M phase

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FYPO:0008223 - normal histone H4-K20 trimethylation during mitotic G2/M phase

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FYPO:0005336 - normal level of histone H3 in cell

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FYPO:0004474 - normal mitotic cell cycle DNA replication checkpoint

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FYPO:0000857 - normal nucleosome positioning in euchromatin

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FYPO:0005614 - normal protein phosphorylation during cellular response to bleomycin

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FYPO:0002099 - normal protein phosphorylation during cellular response to hydroxyurea

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FYPO:0003530 - normal S-phase DNA damage checkpoint

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FYPO:0000764 - resistance to cycloheximide

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FYPO:0009087 - resistance to magnesium chloride and sodium dodecyl sulfate

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FYPO:0000725 - resistance to methyl methanesulfonate

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FYPO:0009043 - resistance to potassium chloride and sodium dodecyl sulfate

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FYPO:0000830 - resistance to vanadate

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FYPO:0000095 - sensitive to bleomycin

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FYPO:0000088 - sensitive to hydroxyurea

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FYPO:0009086 - sensitive to lithium chloride and sodium dodecyl sulfate

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FYPO:0007924 - sensitive to potassium chloride and sodium dodecyl sulfate

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FYPO:0002060 - viable vegetative cell population

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FYPO:0002177 - viable vegetative cell with normal cell morphology

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