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Haploid genotype - sir2-N247A(aa)

Genotype summary

Description
sir2-N247A(aa)
Organism
Schizosaccharomyces pombe (fission yeast)

Allele summary

gene Product Allele name Description Type Expression
sir2 (SPBC16D10.07c)histone deacetylase, Sirtuin family, NAD-dependent Sir2sir2-N247AN247Aamino_acid_mutationNot assayed or wild type

Annotation

Single locus phenotype

FYPO:0000201 - abnormal histone deacetylation during vegetative growth

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FYPO:0004136 - abolished histone H3-K9 dimethylation at telomere during vegetative growth

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FYPO:0002834 - decreased chromatin silencing at centromere

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FYPO:0000893 - increased histone H3-K9 acetylation at centromere during vegetative growth

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FYPO:0002819 - increased histone H3-K9 acetylation at telomere during vegetative growth

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FYPO:0005917 - increased subtelomeric heterochromatin RNA level

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