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Haploid genotype - sir2delta

Genotype summary

Description
sir2delta
Organism
Schizosaccharomyces pombe (fission yeast)

Allele summary

gene Product Allele name Description Type Expression
sir2 (SPBC16D10.07c)histone deacetylase, Sirtuin family, NAD-dependent Sir2sir2deltadeletiondeletionNull

Annotation

Single locus phenotype

FYPO:0000201 - abnormal histone deacetylation during vegetative growth

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FYPO:0003659 - abnormal mating type switching resulting in duplication or deletion in mating-type region

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FYPO:0007336 - abolished chromatin silencing at silent mating-type cassette

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FYPO:0004136 - abolished histone H3-K9 dimethylation at telomere during vegetative growth

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FYPO:0002834 - decreased chromatin silencing at centromere

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FYPO:0003411 - decreased chromatin silencing at centromere inner repeat

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FYPO:0003412 - decreased chromatin silencing at centromere outer repeat

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FYPO:0003216 - decreased chromatin silencing at rDNA

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FYPO:0002827 - decreased chromatin silencing at silent mating-type cassette

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FYPO:0004604 - decreased chromatin silencing at subtelomere

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FYPO:0003352 - decreased DNA double-strand break formation at mating-type locus

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FYPO:0007009 - decreased heterochromatin assembly by small RNA

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FYPO:0007213 - decreased histone H3-K9 dimethylation at heterochromatin island during vegetative growth

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FYPO:0008200 - decreased histone H3-K9 methylation at centromere inner repeat during vegetative growth

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FYPO:0003096 - decreased histone H3-K9 methylation at centromere outer repeat during vegetative growth

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FYPO:0003571 - decreased histone H3-K9 methylation at silent mating-type cassette during vegetative growth

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FYPO:0000470 - decreased mating type switching

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FYPO:0004491 - decreased nucleosome occupancy

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FYPO:0005167 - decreased protein localization to chromatin at centromere inner repeat

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FYPO:0003573 - decreased protein localization to heterochromatin at silent mating-type cassette

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FYPO:0002386 - decreased protein localization to pericentric heterochromatin at centromere outer repeat region

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FYPO:0005939 - decreased replicative lifespan

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FYPO:0009072 - increased cell population growth on lysine nitrogen source

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FYPO:0000636 - increased cell population growth rate

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FYPO:0000220 - increased centromeric outer repeat transcript level

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FYPO:0000332 - increased histone acetylation during vegetative growth

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FYPO:0006815 - increased histone H3-K14 acetylation at centromere inner repeat during vegetative growth

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FYPO:0000966 - increased histone H3-K14 acetylation at centromere outer repeat during vegetative growth

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FYPO:0007633 - increased histone H3-K14 acetylation at silent mating-type cassette during vegetative growth

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FYPO:0005310 - increased histone H3-K14 acetylation during vegetative growth

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FYPO:0004238 - increased histone H3-K4 acetylation during vegetative growth

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FYPO:0000893 - increased histone H3-K9 acetylation at centromere during vegetative growth

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FYPO:0006681 - increased histone H3-K9 acetylation at centromere inner repeat during vegetative growth

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FYPO:0006814 - increased histone H3-K9 acetylation at centromere outer repeat during vegetative growth

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FYPO:0004690 - increased histone H3-K9 acetylation at silent mating-type cassette during vegetative growth

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FYPO:0002819 - increased histone H3-K9 acetylation at telomere during vegetative growth

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FYPO:0000892 - increased histone H3-K9 acetylation during vegetative growth

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FYPO:0000871 - increased histone H3-K9 methylation during vegetative growth

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FYPO:0007631 - increased histone H4-K12 acetylation during vegetative growth

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FYPO:0007632 - increased histone H4-K16 acetylation during vegetative growth

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FYPO:0005309 - increased histone H4-K5 acetylation during vegetative growth

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FYPO:0002173 - increased level of meiotic gene mRNA during vegetative growth

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FYPO:0007937 - increased number of DNA breakpoint junctions during stationary phase

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FYPO:0001327 - increased protein level during vegetative growth

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FYPO:0005917 - increased subtelomeric heterochromatin RNA level

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FYPO:0001309 - increased viability in stationary phase

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FYPO:0006518 - loss of viability in G0

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FYPO:0000245 - loss of viability in stationary phase

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FYPO:0006670 - meiotic cell cycle entry in haploid cell

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FYPO:0002837 - normal centromeric outer repeat transcript-derived siRNA level

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FYPO:0007553 - normal G1 to G0 transition

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FYPO:0006811 - normal gross chromosomal rearrangement frequency

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FYPO:0000969 - normal growth during cellular response to UV

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FYPO:0001164 - normal growth on glucose carbon source

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FYPO:0000964 - normal growth on thiabendazole

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FYPO:0002618 - normal growth on valproic acid

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FYPO:0010017 - normal histone H2B-K33 acetylation during vegetative growth

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FYPO:0000862 - normal histone H3-K9 dimethylation at centromere during vegetative growth

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FYPO:0001513 - normal mitotic sister chromatid segregation

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FYPO:0003576 - normal protein localization to subtelomeric heterochromatin

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FYPO:0001317 - normal RNA level during vegetative growth

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FYPO:0003503 - normal vegetative cell length

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FYPO:0007629 - normal viability during G0

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FYPO:0000764 - resistance to cycloheximide

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FYPO:0001583 - resistance to lithium

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FYPO:0009083 - resistance to lithium chloride and methyl methanesulfonate

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FYPO:0009087 - resistance to magnesium chloride and sodium dodecyl sulfate

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FYPO:0009043 - resistance to potassium chloride and sodium dodecyl sulfate

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FYPO:0003383 - resistance to tert-butyl hydroperoxide

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FYPO:0002617 - sensitive to sodium butyrate

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FYPO:0000091 - sensitive to thiabendazole

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FYPO:0002546 - sensitive to trichostatin A

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FYPO:0000115 - sensitive to valproic acid

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FYPO:0002060 - viable vegetative cell population

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FYPO:0002177 - viable vegetative cell with normal cell morphology

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