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Haploid genotype - spd1delta wdr70delta

Genotype summary

Description
spd1delta wdr70delta
Organism
Schizosaccharomyces pombe (fission yeast)

Allele summary

gene Product Allele name Description Type Expression
spd1 (SPAC29B12.03)ribonucleotide reductase (RNR) inhibitorspd1deltadeletiondeletionNull
wdr70 (SPAC343.17c)DDB1-CUL4-associated factor (DCAF), Wdr70wdr70deltadeletiondeletionNull

Annotation

Multi-locus phenotype

FYPO:0002553 - abnormal double-strand break processing

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FYPO:0003486 - abolished protein localization to double-strand break site

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FYPO:0000705 - abolished protein-protein interaction

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FYPO:0003912 - decreased double-strand break repair via homologous recombination

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FYPO:0005608 - decreased histone H2B-K119 ubiquitination at double-strand break site during vegetative growth

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FYPO:0002474 - decreased protein localization to double-strand break site

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FYPO:0005609 - decreased spatial extent of histone H2B-K119 ubiquitination at double-strand break site during vegetative growth

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FYPO:0005610 - decreased spatial extent of protein localization to double-strand break site

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FYPO:0005606 - delayed onset of protein localization to double-strand break site

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FYPO:0003584 - increased double-strand break repair via nonhomologous end joining

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FYPO:0005604 - increased duration of Rad52 focus presence during cellular response to ionizing radiation

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FYPO:0005605 - increased duration of Ssb1 focus presence during cellular response to ionizing radiation

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FYPO:0005611 - increased H4-K20 dimethylation at double-strand break site during vegetative growth

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FYPO:0002475 - increased protein localization to double-strand break site

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FYPO:0000833 - normal protein level during vegetative growth

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FYPO:0002554 - normal protein localization to double-strand break site

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FYPO:0000089 - sensitive to methyl methanesulfonate

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