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Haploid genotype - swi7-1(G1116E aa)

Genotype summary

Description
swi7-1(G1116E aa)
Organism
Schizosaccharomyces pombe (fission yeast)

Allele summary

gene Product Allele name Description Type Expression
pol1 (SPAC3H5.06c)DNA polymerase alpha catalytic subunitswi7-1G1116Eamino_acid_mutationNot assayed or wild type

Annotation

Single locus phenotype

FYPO:0000468 - abnormal mating type switching

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FYPO:0006436 - abnormal S-phase DNA damage checkpoint during cellular response to methyl methanesulfonate

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FYPO:0000469 - abolished mating type switching

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FYPO:0006438 - alkylation damage repair intermediates absent

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FYPO:0003165 - cut with abnormal chromosome segregation

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FYPO:0003217 - decreased chromatin silencing at centromere central core

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FYPO:0003412 - decreased chromatin silencing at centromere outer repeat

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FYPO:0002827 - decreased chromatin silencing at silent mating-type cassette

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FYPO:0003352 - decreased DNA double-strand break formation at mating-type locus

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FYPO:0000470 - decreased mating type switching

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FYPO:0003573 - decreased protein localization to heterochromatin at silent mating-type cassette

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FYPO:0002386 - decreased protein localization to pericentric heterochromatin at centromere outer repeat region

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FYPO:0002387 - decreased protein localization to subtelomeric heterochromatin during vegetative growth

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FYPO:0001645 - decreased protein-protein interaction

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FYPO:0006439 - increased level of X-shaped replication intermediates

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FYPO:0000473 - increased mitotic recombination

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FYPO:0000972 - increased number of Rad52 foci during vegetative growth

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FYPO:0002541 - increased protein localization to nucleoplasm

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FYPO:0006437 - normal mitotic DNA damage checkpoint during cellular response to methyl methanesulfonate

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FYPO:0001357 - normal vegetative cell population growth

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FYPO:0000088 - sensitive to hydroxyurea

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FYPO:0000089 - sensitive to methyl methanesulfonate

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FYPO:0000268 - sensitive to UV during vegetative growth

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