id: gomodel:67369e7600002505
title: mitotic spindle assembly checkpoint signalling (GO:0007094)
taxon: NCBITaxon:4896
status: production
date_modified: '2026-03-16'
comments:
- '*****should be outer kinetochore

  *****Add mitotic metaphase'
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        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2026-03-12'
      provided_by:
      - http://www.pombase.org
    term: GO:0000776
  part_of:
    type: BiologicalProcessAssociation
    evidence:
    - term: ECO:0000315
      reference: PMID:16179942
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-07-26'
        provided_by:
        - http://www.pombase.org
    - term: ECO:0000315
      reference: PMID:22825872
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-07-26'
        provided_by:
        - http://www.pombase.org
    - term: ECO:0000315
      reference: PMID:22521786
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-07-26'
        provided_by:
        - http://www.pombase.org
    - term: ECO:0000315
      reference: PMID:9864354
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-07-26'
        provided_by:
        - http://www.pombase.org
    - term: ECO:0000315
      reference: PMID:24477934
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-07-26'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2026-03-12'
      provided_by:
      - http://www.pombase.org
    term: GO:0007094
- id: gomodel:67369e7600002505/67369e7600002707
  enabled_by:
    type: EnabledByGeneProductAssociation
    evidence:
    - term: ECO:0000353
      reference: PMID:15525673
      with_objects:
      - PomBase:SPCC1322.12c
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2024-11-30'
        provided_by:
        - http://www.pombase.org
    - term: ECO:0000353
      reference: PMID:11909965
      with_objects:
      - PomBase:SPCC1795.01c
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2024-11-30'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2024-11-30'
      provided_by:
      - http://www.pombase.org
    term: PomBase:SPAC23H3.08c
  molecular_function:
    type: MolecularFunctionAssociation
    term: GO:0005515
  occurs_in:
    type: CellularAnatomicalEntityAssociation
    evidence:
    - term: ECO:0000314
      reference: PMID:15509783
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2024-11-30'
        provided_by:
        - http://www.pombase.org
    - term: ECO:0000314
      reference: PMID:11909965
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2024-11-30'
        provided_by:
        - http://www.pombase.org
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN000103865
      - TAIR:locus:2091211
      - SGD:S000005552
      - PomBase:SPAC23H3.08c
      - UniProtKB:O43684
      - MGI:MGI:1343463
      - FB:FBgn0025457
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2024-11-30'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2024-11-30'
      provided_by:
      - http://www.pombase.org
    term: GO:0000776
  part_of:
    type: BiologicalProcessAssociation
    evidence:
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN000103865
      - WB:WBGene00013209
      - TAIR:locus:2091211
      - FB:FBgn0025457
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2024-11-30'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2024-11-30'
      provided_by:
      - http://www.pombase.org
    term: GO:0007094
molecules: []
objects:
- id: GO:0140483
  label: kinetochore adaptor activity
  type: gocam:Object
- id: PomBase:SPBC3D6.04c
  label: mad1 Spom
  type: gocam:Object
- id: GO:0007094
  label: mitotic spindle assembly checkpoint signaling
  type: gocam:Object
- id: GO:0000776
  label: kinetochore
  type: gocam:Object
- id: ECO:0000315
  label: mutant phenotype evidence used in manual assertion
  type: gocam:Object
- id: ECO:0000318
  label: biological aspect of ancestor evidence used in manual assertion
  type: gocam:Object
- id: ECO:0000314
  label: direct assay evidence used in manual assertion
  type: gocam:Object
- id: GO:1990757
  label: ubiquitin ligase activator activity
  type: gocam:Object
- id: PomBase:SPAC821.08c
  label: slp1 Spom
  type: gocam:Object
- id: ECO:0000303
  label: author statement without traceable support used in manual assertion
  type: gocam:Object
- id: ECO:0000269
  label: experimental evidence used in manual assertion
  type: gocam:Object
- id: ECO:0000304
  label: author statement supported by traceable reference used in manual assertion
  type: gocam:Object
- id: GO:0003674
  label: molecular_function
  type: gocam:Object
- id: PomBase:SPCC1795.01c
  label: mad3 Spom
  type: gocam:Object
- id: GO:0033597
  label: mitotic checkpoint complex
  type: gocam:Object
- id: GO:0035591
  label: signaling adaptor activity
  type: gocam:Object
- id: PomBase:SPCC1020.02
  label: spc7 Spom
  type: gocam:Object
- id: GO:0180019
  label: Knl1/Spc105 complex
  type: gocam:Object
- id: ECO:0000250
  label: sequence similarity evidence used in manual assertion
  type: gocam:Object
- id: GO:0061630
  label: ubiquitin protein ligase activity
  type: gocam:Object
- id: PomBase:SPAC343.03
  label: apc11 Spom
  type: gocam:Object
- id: GO:0051306
  label: mitotic sister chromatid separation
  type: gocam:Object
- id: ECO:0000501
  label: evidence used in automatic assertion
  type: gocam:Object
- id: GO:0004866
  label: endopeptidase inhibitor activity
  type: gocam:Object
- id: PomBase:SPBC14C8.01c
  label: cut2 Spom
  type: gocam:Object
- id: GO:1990520
  label: separase-securin complex
  type: gocam:Object
- id: GO:0004197
  label: cysteine-type endopeptidase activity
  type: gocam:Object
- id: PomBase:SPCC5E4.04
  label: cut1 Spom
  type: gocam:Object
- id: GO:0000089
  label: mitotic metaphase
  type: gocam:Object
- id: GO:0000091
  label: mitotic anaphase A
  type: gocam:Object
- id: GO:0061631
  label: ubiquitin conjugating enzyme activity
  type: gocam:Object
- id: PomBase:SPCC1259.15c
  label: ubc11 Spom
  type: gocam:Object
- id: GO:0005634
  label: nucleus
  type: gocam:Object
- id: ECO:0007005
  label: high throughput direct assay evidence used in manual assertion
  type: gocam:Object
- id: PomBase:SPBC119.02
  label: ubc4 Spom
  type: gocam:Object
- id: GO:0005515
  label: protein binding
  type: gocam:Object
- id: PomBase:SPAC23H3.08c
  label: bub3 Spom
  type: gocam:Object
- id: ECO:0000353
  label: physical interaction evidence used in manual assertion
  type: gocam:Object
- id: GO:0061776
  label: ATP-dependent topological DNA co-entrapment activity
  type: gocam:Object
- id: PomBase:SPCC338.17c
  label: rad21 Spom
  type: gocam:Object
- id: GO:0007064
  label: mitotic sister chromatid cohesion
  type: gocam:Object
- id: GO:0005721
  label: pericentric heterochromatin
  type: gocam:Object
- id: PomBase:SPBC20F10.06
  label: mad2 Spom
  type: gocam:Object
- id: GO:0004674
  label: protein serine/threonine kinase activity
  type: gocam:Object
- id: PomBase:SPBC106.01
  label: mph1 Spom
  type: gocam:Object
- id: GO:0004693
  label: cyclin-dependent protein serine/threonine kinase activity
  type: gocam:Object
- id: PomBase:SPBC11B10.09
  label: cdc2 Spom
  type: gocam:Object
- id: GO:0090267
  label: positive regulation of mitotic cell cycle spindle assembly checkpoint
  type: gocam:Object
- id: PomBase:SPCC1322.12c
  label: bub1 Spom
  type: gocam:Object
- id: PomBase:SPCC320.13c
  label: ark1 Spom
  type: gocam:Object
- id: GO:0004722
  label: protein serine/threonine phosphatase activity
  type: gocam:Object
- id: PomBase:SPBC776.02c
  label: dis2 Spom
  type: gocam:Object
- id: GO:1902426
  label: deactivation of mitotic spindle assembly checkpoint
  type: gocam:Object
- id: GO:0005680
  label: anaphase-promoting complex
  type: gocam:Object
- id: ECO:0000305
  label: curator inference used in manual assertion
  type: gocam:Object
provenances:
- contributor:
  - https://orcid.org/0000-0001-6330-7526
  date: '2026-03-16'
  provided_by:
  - http://www.pombase.org
