id: gomodel:678073a900003902
title: L-proline biosynthetic process (GO:0055129),  L-proline catabolic process (GO:0006562),
  L-glutamine biosynthetic process (GO:1901704)
taxon: NCBITaxon:4896
status: production
date_modified: '2026-04-19'
comments:
- 'Automated change 2026-01-22: GO:0006542 replaced by GO:1901704'
- 'Automated change 2026-01-22: GO:0010121 replaced by GO:0006527'
- 'Automated change 2026-01-22: GO:0010133 replaced by GO:0006562'
activities:
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    term: GO:0005759
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      - http://www.pombase.org
    term: PomBase:SPAC17H9.13c
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      with_objects:
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      - TAIR:locus:2200580
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      - http://www.pombase.org
    term: GO:0005829
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    type: BiologicalProcessAssociation
    evidence:
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      reference: PMID:17248775
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    term: GO:0055129
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- id: gomodel:678073a900003902/678073a900003934
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    predicate: RO:0002234
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    predicate: RO:0002233
    molecule: gomodel:678073a900003902/678073a900003958
molecules:
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      - http://www.pombase.org
    term: GO:0005829
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      - http://www.pombase.org
    term: GO:0005829
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      - http://www.pombase.org
    term: GO:0005829
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      - http://www.pombase.org
    term: GO:0005829
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    term: GO:0005759
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      - http://www.pombase.org
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      - http://www.pombase.org
    term: GO:0005759
- id: gomodel:678073a900003902/678073a900004060
  term: CHEBI:29985
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    type: CellularAnatomicalEntityAssociation
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      - http://www.pombase.org
    term: GO:0005759
- id: gomodel:678073a900003902/68b0f0d000007461
  term: PomBase:SPMITTRNAGLN.01
- id: gomodel:678073a900003902/68b0f0d000000260
  term: PomBase:SPMITTRNAPRO.01
- id: gomodel:678073a900003902/67c10cc400006995
  term: CHEBI:16199
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    type: CellularAnatomicalEntityAssociation
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    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-03-21'
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      - http://www.pombase.org
    term: GO:0005829
- id: gomodel:678073a900003902/678073a900003933
  term: CHEBI:35179
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    type: CellularAnatomicalEntityAssociation
    evidence: []
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      - https://orcid.org/0000-0001-6330-7526
      date: '2025-03-21'
      provided_by:
      - http://www.pombase.org
    term: GO:0005829
- id: gomodel:678073a900003902/678073a900003964
  term: CHEBI:15893
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    type: CellularAnatomicalEntityAssociation
    evidence: []
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
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      - http://www.pombase.org
    term: GO:0005829
- id: gomodel:678073a900003902/68b0f0d000007466
  term: PomBase:SPMITTRNAGLU.01
- id: gomodel:678073a900003902/678073a900004046
  term: CHEBI:58066
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    type: CellularAnatomicalEntityAssociation
    evidence: []
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-03-21'
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      - http://www.pombase.org
    term: GO:0005759
- id: gomodel:678073a900003902/67e5e74400000498
  term: CHEBI:28938
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    type: CellularAnatomicalEntityAssociation
    evidence: []
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-07-08'
      provided_by:
      - http://www.pombase.org
    term: GO:0005829
objects:
- id: GO:0005829
  label: cytosol
  type: gocam:Object
- id: GO:0005759
  label: mitochondrial matrix
  type: gocam:Object
- id: GO:0004053
  label: arginase activity
  type: gocam:Object
- id: PomBase:SPBP26C9.02c
  label: car1 Spom
  type: gocam:Object
- id: GO:0000050
  label: urea cycle
  type: gocam:Object
- id: ECO:0000316
  label: genetic interaction evidence used in manual assertion
  type: gocam:Object
- id: ECO:0000318
  label: biological aspect of ancestor evidence used in manual assertion
  type: gocam:Object
- id: CHEBI:16199
  label: urea
  type: gocam:Object
- id: CHEBI:60039
  label: L-proline zwitterion
  type: gocam:Object
- id: GO:0004356
  label: glutamine synthetase activity
  type: gocam:Object
- id: PomBase:SPAC23H4.06
  label: gln1 Spom
  type: gocam:Object
- id: GO:1901704
  label: L-glutamine biosynthetic process
  type: gocam:Object
- id: ECO:0000314
  label: direct assay evidence used in manual assertion
  type: gocam:Object
- id: ECO:0000315
  label: mutant phenotype evidence used in manual assertion
  type: gocam:Object
- id: ECO:0007005
  label: high throughput direct assay evidence used in manual assertion
  type: gocam:Object
- id: CHEBI:28938
  label: ammonium
  type: gocam:Object
- id: CHEBI:58359
  label: L-glutamine zwitterion
  type: gocam:Object
- id: GO:0015186
  label: L-glutamine transmembrane transporter activity
  type: gocam:Object
- id: CHEBI:36080
  label: protein
  type: gocam:Object
- id: GO:0006868
  label: L-glutamine transport
  type: gocam:Object
- id: GO:0031966
  label: mitochondrial membrane
  type: gocam:Object
- id: GO:0015193
  label: L-proline transmembrane transporter activity
  type: gocam:Object
- id: GO:0015824
  label: proline transport
  type: gocam:Object
- id: GO:0004587
  label: L-ornithine transaminase activity
  type: gocam:Object
- id: PomBase:SPBC21C3.08c
  label: car2 Spom
  type: gocam:Object
- id: GO:0006527
  label: L-arginine catabolic process
  type: gocam:Object
- id: CHEBI:46911
  label: L-ornithinium(1+)
  type: gocam:Object
- id: CHEBI:35179
  label: 2-oxo monocarboxylic acid anion
  type: gocam:Object
- id: GO:0004350
  label: glutamate-5-semialdehyde dehydrogenase activity
  type: gocam:Object
- id: PomBase:SPAC821.11
  label: pro1 Spom
  type: gocam:Object
- id: GO:0055129
  label: L-proline biosynthetic process
  type: gocam:Object
- id: ECO:0000269
  label: experimental evidence used in manual assertion
  type: gocam:Object
- id: GO:0004349
  label: glutamate 5-kinase activity
  type: gocam:Object
- id: PomBase:SPAC17H9.13c
  label: pro2 Spom
  type: gocam:Object
- id: GO:0004735
  label: pyrroline-5-carboxylate reductase activity
  type: gocam:Object
- id: PomBase:SPAPYUG7.05
  label: pro3 Spom
  type: gocam:Object
- id: CHEBI:29985
  label: L-glutamate(1-)
  type: gocam:Object
- id: CHEBI:58274
  label: L-gamma-glutamyl phosphate(2-)
  type: gocam:Object
- id: CHEBI:58066
  label: L-glutamic 5-semialdehyde zwitterion
  type: gocam:Object
- id: CHEBI:15893
  label: 1-pyrroline-5-carboxylate
  type: gocam:Object
- id: GO:0004657
  label: proline dehydrogenase activity
  type: gocam:Object
- id: PomBase:SPCC70.03c
  label: put1 Spom
  type: gocam:Object
- id: GO:0006562
  label: L-proline catabolic process
  type: gocam:Object
- id: ECO:0000250
  label: sequence similarity evidence used in manual assertion
  type: gocam:Object
- id: GO:0003842
  label: L-glutamate gamma-semialdehyde dehydrogenase activity
  type: gocam:Object
- id: PomBase:SPBC24C6.04
  label: put2 Spom
  type: gocam:Object
- id: GO:0004827
  label: proline-tRNA ligase activity
  type: gocam:Object
- id: PomBase:SPBC24C6.03
  label: SPBC24C6.03 Spom
  type: gocam:Object
- id: GO:0070157
  label: mitochondrial prolyl-tRNA aminoacylation
  type: gocam:Object
- id: ECO:0000305
  label: curator inference used in manual assertion
  type: gocam:Object
- id: PomBase:SPMITTRNAPRO.01
  label: SPMITTRNAPRO.01 Spom
  type: gocam:Object
- id: GO:0050567
  label: glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity
  type: gocam:Object
- id: GO:0030956
  label: glutamyl-tRNA(Gln) amidotransferase complex
  type: gocam:Object
- id: PomBase:SPBC646.03
  label: gta1 Spom
  type: gocam:Object
- id: PomBase:SPAC343.13
  label: gta2 Spom
  type: gocam:Object
- id: PomBase:SPCC777.11
  label: gta3 Spom
  type: gocam:Object
- id: GO:0000064
  label: L-ornithine transmembrane transporter activity
  type: gocam:Object
- id: PomBase:SPBC29A3.11c
  label: ort1 Spom
  type: gocam:Object
- id: GO:1990575
  label: mitochondrial L-ornithine transmembrane transport
  type: gocam:Object
- id: GO:0005743
  label: mitochondrial inner membrane
  type: gocam:Object
- id: ECO:0000266
  label: sequence orthology evidence used in manual assertion
  type: gocam:Object
- id: PomBase:SPAC3H1.07
  label: aru1 Spom
  type: gocam:Object
- id: PomBase:SPMITTRNAGLN.01
  label: SPMITTRNAGLN.01 Spom
  type: gocam:Object
- id: GO:0004818
  label: glutamate-tRNA ligase activity
  type: gocam:Object
- id: PomBase:SPAPB1A10.11c
  label: mse1 Spom
  type: gocam:Object
- id: GO:0006424
  label: glutamyl-tRNA aminoacylation
  type: gocam:Object
- id: PomBase:SPMITTRNAGLU.01
  label: SPMITTRNAGLU.01 Spom
  type: gocam:Object
- id: GO:0043039
  label: tRNA aminoacylation
  type: gocam:Object
provenances:
- contributor:
  - https://orcid.org/0000-0001-6330-7526
  - https://orcid.org/0009-0003-9059-1333
  date: '2026-04-19'
  provided_by:
  - http://www.pombase.org
