id: gomodel:67ae98b500000055
title: iron import into cell (GO:0033212) / siderophore biosynthetic process (GO:0019290)
taxon: NCBITaxon:4896
status: production
date_modified: '2026-04-23'
comments:
- 'Automated change 2026-04-23: GO:0016410 replaced by GO:0016747'
activities:
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      date: '2025-02-16'
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    term: CHEBI:36080
  molecular_function:
    type: MolecularFunctionAssociation
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      provided_by:
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    term: PomBase:SPAC23G3.02c
  molecular_function:
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    evidence:
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    term: GO:0031169
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    term: PomBase:SPAC1F8.02c
  molecular_function:
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    term: GO:0009897
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    evidence:
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      reference: '

        PMID:25733668'
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      date: '2025-02-14'
      provided_by:
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    term: GO:0140420
  molecular_associations:
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    part_of:
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      term: GO:0033573
  molecular_function:
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    term: PomBase:SPBC17G9.06c
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- id: gomodel:67ae98b500000055/67b1629100004444
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      - http://www.pombase.org
    term: GO:0005829
- id: gomodel:67ae98b500000055/67b1629100002465
  term: CHEBI:29034
  located_in:
    type: CellularAnatomicalEntityAssociation
    evidence: []
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2026-03-01'
      provided_by:
      - http://www.pombase.org
    term: GO:0005576
objects:
- id: GO:0016722
  label: oxidoreductase activity, acting on metal ions
  type: gocam:Object
- id: PomBase:SPBC1683.09c
  label: frp1 Spom
  type: gocam:Object
- id: GO:0009897
  label: external side of plasma membrane
  type: gocam:Object
- id: ECO:0000315
  label: mutant phenotype evidence used in manual assertion
  type: gocam:Object
- id: ECO:0000304
  label: author statement supported by traceable reference used in manual assertion
  type: gocam:Object
- id: GO:0004322
  label: ferroxidase activity
  type: gocam:Object
- id: PomBase:SPAC1F7.08
  label: fio1 Spom
  type: gocam:Object
- id: GO:0033215
  label: reductive iron assimilation
  type: gocam:Object
- id: ECO:0000318
  label: biological aspect of ancestor evidence used in manual assertion
  type: gocam:Object
- id: GO:0061840
  label: high-affinity ferrous iron transmembrane transporter activity
  type: gocam:Object
- id: PomBase:SPAC1F7.07c
  label: fip1 Spom
  type: gocam:Object
- id: GO:0005886
  label: plasma membrane
  type: gocam:Object
- id: ECO:0000316
  label: genetic interaction evidence used in manual assertion
  type: gocam:Object
- id: GO:0015343
  label: siderophore-iron transmembrane transporter activity
  type: gocam:Object
- id: PomBase:SPBC4F6.09
  label: str1 Spom
  type: gocam:Object
- id: GO:0033214
  label: siderophore-iron import into cell
  type: gocam:Object
- id: CHEBI:5019
  label: ferrichrome
  type: gocam:Object
- id: GO:1904091
  label: non-ribosomal peptide synthetase activity
  type: gocam:Object
- id: PomBase:SPAC23G3.02c
  label: sib1 Spom
  type: gocam:Object
- id: GO:0031169
  label: ferrichrome biosynthetic process
  type: gocam:Object
- id: GO:0005829
  label: cytosol
  type: gocam:Object
- id: ECO:0000303
  label: author statement without traceable support used in manual assertion
  type: gocam:Object
- id: ECO:0007005
  label: high throughput direct assay evidence used in manual assertion
  type: gocam:Object
- id: GO:0031172
  label: ornithine N5-monooxygenase activity
  type: gocam:Object
- id: PomBase:SPAC23G3.03
  label: sib2 Spom
  type: gocam:Object
- id: GO:0016747
  label: acyltransferase activity, transferring groups other than amino-acyl groups
  type: gocam:Object
- id: PomBase:SPBC17G9.06c
  label: sib3 Spom
  type: gocam:Object
- id: ECO:0000255
  label: match to sequence model evidence used in manual assertion
  type: gocam:Object
- id: GO:0140488
  label: heme receptor activity
  type: gocam:Object
- id: PomBase:SPAC1F8.02c
  label: shu1 Spom
  type: gocam:Object
- id: GO:0140420
  label: heme import into cell
  type: gocam:Object
- id: ECO:0000314
  label: direct assay evidence used in manual assertion
  type: gocam:Object
- id: ECO:0000269
  label: experimental evidence used in manual assertion
  type: gocam:Object
- id: CHEBI:30413
  label: heme
  type: gocam:Object
- id: GO:0015232
  label: heme transmembrane transporter activity
  type: gocam:Object
- id: PomBase:SPAC1F8.03c
  label: str3 Spom
  type: gocam:Object
- id: GO:1904334
  label: heme import across plasma membrane
  type: gocam:Object
- id: GO:0005576
  label: extracellular region
  type: gocam:Object
- id: GO:0042929
  label: ferrichrome transmembrane transporter activity
  type: gocam:Object
- id: CHEBI:36080
  label: protein
  type: gocam:Object
- id: CHEBI:29034
  label: iron(3+)
  type: gocam:Object
- id: CHEBI:29033
  label: iron(2+)
  type: gocam:Object
- id: GO:0001227
  label: DNA-binding transcription repressor activity, RNA polymerase II-specific
  type: gocam:Object
- id: PomBase:SPAC23E2.01
  label: fep1 Spom
  type: gocam:Object
- id: GO:1904439
  label: negative regulation of iron ion import across plasma membrane
  type: gocam:Object
- id: GO:0005634
  label: nucleus
  type: gocam:Object
- id: GO:0003713
  label: transcription coactivator activity
  type: gocam:Object
- id: PomBase:SPAC8C9.11
  label: fra2 Spom
  type: gocam:Object
- id: GO:0045944
  label: positive regulation of transcription by RNA polymerase II
  type: gocam:Object
- id: ECO:0000353
  label: physical interaction evidence used in manual assertion
  type: gocam:Object
- id: CHEBI:46911
  label: L-ornithinium(1+)
  type: gocam:Object
- id: CHEBI:78275
  label: N(5)-hydroxy-L-ornithine zwitterion
  type: gocam:Object
- id: GO:0004053
  label: arginase activity
  type: gocam:Object
- id: PomBase:SPBP26C9.02c
  label: car1 Spom
  type: gocam:Object
- id: GO:0000050
  label: urea cycle
  type: gocam:Object
- id: PomBase:SPAC3H1.07
  label: aru1 Spom
  type: gocam:Object
- id: CHEBI:16199
  label: urea
  type: gocam:Object
- id: GO:0000064
  label: L-ornithine transmembrane transporter activity
  type: gocam:Object
- id: PomBase:SPBC29A3.11c
  label: ort1 Spom
  type: gocam:Object
- id: GO:1990575
  label: mitochondrial L-ornithine transmembrane transport
  type: gocam:Object
- id: GO:0005743
  label: mitochondrial inner membrane
  type: gocam:Object
- id: ECO:0000266
  label: sequence orthology evidence used in manual assertion
  type: gocam:Object
- id: ECO:0000250
  label: sequence similarity evidence used in manual assertion
  type: gocam:Object
- id: GO:0030139
  label: endocytic vesicle
  type: gocam:Object
- id: ECO:0000312
  label: imported information used in manual assertion
  type: gocam:Object
- id: GO:0033212
  label: iron import into cell
  type: gocam:Object
- id: ECO:0000305
  label: curator inference used in manual assertion
  type: gocam:Object
- id: GO:0033573
  label: high-affinity iron permease complex
  type: gocam:Object
provenances:
- contributor:
  - https://orcid.org/0000-0001-6330-7526
  - https://orcid.org/0009-0003-9059-1333
  date: '2026-04-23'
  provided_by:
  - http://www.pombase.org
