id: gomodel:6690711d00002706
title: L-isoleucine biosynthetic process  (GO:1901705), L-leucine biosynthetic process
  (GO:0009098)
taxon: NCBITaxon:4896
status: production
date_modified: '2026-04-15'
comments:
- 'Automated change 2026-02-12: GO:0009097 replaced by GO:1901705'
- https://pubmed.ncbi.nlm.nih.gov/37455545/#:~:text=Branched%2Dchain%20amino%20acids%20(BCAAs,in%20the%20yeast%20Saccharomyces%20cerevisiae.
activities:
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        date: '2025-01-19'
        provided_by:
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      with_objects:
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      - UniProtKB:P9WKJ5
      - UniProtKB:Q4X099
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    term: PomBase:SPAC17G8.06c
  molecular_function:
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    term: GO:0005759
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  causal_associations:
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- id: gomodel:6690711d00002706/69a0c46f00003130
  enabled_by:
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    term: PomBase:SPBC1604.04
  molecular_function:
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    term: GO:0005743
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    term: PomBase:SPBC3E7.16c
  molecular_function:
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      - https://orcid.org/0000-0001-6330-7526
      date: '2025-03-21'
      provided_by:
      - http://www.pombase.org
    term: GO:0005759
- id: gomodel:6690711d00002706/678073a900001365
  term: CHEBI:1178
  located_in:
    type: CellularAnatomicalEntityAssociation
    evidence: []
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-03-11'
      provided_by:
      - http://www.pombase.org
    term: GO:0005759
- id: gomodel:6690711d00002706/68b0f0d000007156
  term: CHEBI:29985
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    type: CellularAnatomicalEntityAssociation
    evidence: []
    provenances:
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      - https://orcid.org/0009-0003-9059-1333
      date: '2025-09-17'
      provided_by:
      - http://www.pombase.org
    term: GO:0005759
- id: gomodel:6690711d00002706/678073a900001316
  term: CHEBI:15361
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    type: CellularAnatomicalEntityAssociation
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    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-03-06'
      provided_by:
      - http://www.pombase.org
    term: GO:0005759
- id: gomodel:6690711d00002706/68b0f0d000000217
  term: PomBase:SPMITTRNAILE.02
- id: gomodel:6690711d00002706/68b0f0d000000216
  term: PomBase:SPMITTRNAILE.01
- id: gomodel:6690711d00002706/68b0f0d000000199
  term: PomBase:SPMITTRNALEU.02
- id: gomodel:6690711d00002706/68b0f0d000000198
  term: PomBase:SPMITTRNALEU.01
- id: gomodel:6690711d00002706/6690711d00002716
  term: CHEBI:26986
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    type: CellularAnatomicalEntityAssociation
    evidence: []
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-03-21'
      provided_by:
      - http://www.pombase.org
    term: GO:0005759
- id: gomodel:6690711d00002706/678073a900001364
  term: CHEBI:11851
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    type: CellularAnatomicalEntityAssociation
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    provenances:
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      - https://orcid.org/0000-0001-6330-7526
      date: '2025-03-21'
      provided_by:
      - http://www.pombase.org
    term: GO:0005759
objects:
- id: ECO:0000303
  label: author statement without traceable support used in manual assertion
  type: gocam:Object
- id: GO:0004794
  label: threonine deaminase activity
  type: gocam:Object
- id: PomBase:SPBC1677.03c
  label: tda1 Spom
  type: gocam:Object
- id: GO:1901705
  label: L-isoleucine biosynthetic process
  type: gocam:Object
- id: GO:0005759
  label: mitochondrial matrix
  type: gocam:Object
- id: ECO:0000314
  label: direct assay evidence used in manual assertion
  type: gocam:Object
- id: ECO:0000318
  label: biological aspect of ancestor evidence used in manual assertion
  type: gocam:Object
- id: ECO:0000305
  label: curator inference used in manual assertion
  type: gocam:Object
- id: CHEBI:26986
  label: threonine
  type: gocam:Object
- id: GO:0003984
  label: acetolactate synthase activity
  type: gocam:Object
- id: PomBase:SPBP35G2.07
  label: ilv1 Spom
  type: gocam:Object
- id: ECO:0000316
  label: genetic interaction evidence used in manual assertion
  type: gocam:Object
- id: ECO:0000269
  label: experimental evidence used in manual assertion
  type: gocam:Object
- id: GO:1990610
  label: acetolactate synthase regulator activity
  type: gocam:Object
- id: PomBase:SPBC14C8.04
  label: ilv6 Spom
  type: gocam:Object
- id: ECO:0000250
  label: sequence similarity evidence used in manual assertion
  type: gocam:Object
- id: ECO:0000266
  label: sequence orthology evidence used in manual assertion
  type: gocam:Object
- id: CHEBI:28938
  label: ammonium
  type: gocam:Object
- id: CHEBI:58476
  label: (2S)-2-hydroxy-2-methyl-3-oxobutanoate
  type: gocam:Object
- id: CHEBI:16763
  label: 2-oxobutanoate
  type: gocam:Object
- id: GO:0004455
  label: ketol-acid reductoisomerase activity
  type: gocam:Object
- id: PomBase:SPBC56F2.12
  label: ilv5 Spom
  type: gocam:Object
- id: GO:0004160
  label: dihydroxy-acid dehydratase activity
  type: gocam:Object
- id: PomBase:SPAC17G8.06c
  label: ilv3 Spom
  type: gocam:Object
- id: ECO:0000315
  label: mutant phenotype evidence used in manual assertion
  type: gocam:Object
- id: GO:0052656
  label: L-isoleucine:2-oxoglutarate transaminase activity
  type: gocam:Object
- id: PomBase:SPBC428.02c
  label: eca39 Spom
  type: gocam:Object
- id: CHEBI:58045
  label: L-isoleucine zwitterion
  type: gocam:Object
- id: GO:0004742
  label: dihydrolipoyllysine-residue acetyltransferase activity
  type: gocam:Object
- id: PomBase:SPCC794.07
  label: lat1 Spom
  type: gocam:Object
- id: GO:0006086
  label: pyruvate decarboxylation to acetyl-CoA
  type: gocam:Object
- id: GO:0005739
  label: mitochondrion
  type: gocam:Object
- id: GO:0034658
  label: isopropylmalate transmembrane transporter activity
  type: gocam:Object
- id: PomBase:SPAC139.02c
  label: oac1 Spom
  type: gocam:Object
- id: GO:1990556
  label: mitochondrial isopropylmalate transmembrane transport
  type: gocam:Object
- id: GO:0005743
  label: mitochondrial inner membrane
  type: gocam:Object
- id: CHEBI:1178
  label: (2S)-2-isopropylmalate(2-)
  type: gocam:Object
- id: GO:0005829
  label: cytosol
  type: gocam:Object
- id: GO:0004822
  label: isoleucine-tRNA ligase activity
  type: gocam:Object
- id: PomBase:SPCC18B5.08c
  label: ism1 Spom
  type: gocam:Object
- id: GO:0070152
  label: mitochondrial isoleucyl-tRNA aminoacylation
  type: gocam:Object
- id: GO:0015190
  label: L-leucine transmembrane transporter activity
  type: gocam:Object
- id: CHEBI:36080
  label: protein
  type: gocam:Object
- id: GO:0015820
  label: L-leucine transport
  type: gocam:Object
- id: CHEBI:57427
  label: L-leucine zwitterion
  type: gocam:Object
- id: GO:0009098
  label: L-leucine biosynthetic process
  type: gocam:Object
- id: CHEBI:15361
  label: pyruvate
  type: gocam:Object
- id: CHEBI:49256
  label: (S)-2-acetyl-2-hydroxybutanoate
  type: gocam:Object
- id: GO:0006551
  label: L-leucine metabolic process
  type: gocam:Object
- id: CHEBI:49072
  label: (R)-2,3-dihydroxy-3-methylbutanoate
  type: gocam:Object
- id: CHEBI:28654
  label: 3-methyl-2-oxovalerate
  type: gocam:Object
- id: GO:0003852
  label: 2-isopropylmalate synthase activity
  type: gocam:Object
- id: PomBase:SPBC3E7.16c
  label: leu3 Spom
  type: gocam:Object
- id: ECO:0007005
  label: high throughput direct assay evidence used in manual assertion
  type: gocam:Object
- id: CHEBI:15351
  label: acetyl-CoA
  type: gocam:Object
- id: CHEBI:11851
  label: 3-methyl-2-oxobutanoate
  type: gocam:Object
- id: GO:0003861
  label: 3-isopropylmalate dehydratase activity
  type: gocam:Object
- id: PomBase:SPAC9E9.03
  label: leu2 Spom
  type: gocam:Object
- id: GO:0003862
  label: 3-isopropylmalate dehydrogenase activity
  type: gocam:Object
- id: PomBase:SPBC1A4.02c
  label: leu1 Spom
  type: gocam:Object
- id: CHEBI:35121
  label: (2R,3S)-3-isopropylmalate(2-)
  type: gocam:Object
- id: GO:0052654
  label: L-leucine:2-oxoglutarate transaminase activity
  type: gocam:Object
- id: CHEBI:15603
  label: L-leucine
  type: gocam:Object
- id: GO:0004823
  label: leucine-tRNA ligase activity
  type: gocam:Object
- id: PomBase:SPAC4G8.09
  label: SPAC4G8.09 Spom
  type: gocam:Object
- id: GO:0006429
  label: leucyl-tRNA aminoacylation
  type: gocam:Object
- id: PomBase:SPMITTRNALEU.01
  label: SPMITTRNALEU.01 Spom
  type: gocam:Object
- id: PomBase:SPMITTRNALEU.02
  label: SPMITTRNALEU.02 Spom
  type: gocam:Object
- id: PomBase:SPMITTRNAILE.01
  label: SPMITTRNAILE.01 Spom
  type: gocam:Object
- id: PomBase:SPMITTRNAILE.02
  label: SPMITTRNAILE.02 Spom
  type: gocam:Object
- id: GO:0004021
  label: L-alanine:2-oxoglutarate transaminase activity
  type: gocam:Object
- id: PomBase:SPBC582.08
  label: alt1 Spom
  type: gocam:Object
- id: CHEBI:29985
  label: L-glutamate(1-)
  type: gocam:Object
- id: CHEBI:29160
  label: Ile-tRNA(Ile)
  type: gocam:Object
- id: GO:0090422
  label: thiamine pyrophosphate transmembrane transporter activity
  type: gocam:Object
- id: PomBase:SPBC1604.04
  label: SPBC1604.04 Spom
  type: gocam:Object
- id: GO:1990545
  label: mitochondrial thiamine pyrophosphate transmembrane transport
  type: gocam:Object
- id: CHEBI:58937
  label: thiamine(1+) diphosphate(3-)
  type: gocam:Object
- id: GO:0042853
  label: L-alanine catabolic process
  type: gocam:Object
provenances:
- contributor:
  - https://orcid.org/0000-0001-6330-7526
  - https://orcid.org/0009-0003-9059-1333
  date: '2026-04-15'
  provided_by:
  - http://www.pombase.org
