id: gomodel:67c10cc400000238
title: '''de novo'' cotranslational protein folding (GO:0051083)'
taxon: NCBITaxon:4896
status: production
date_modified: '2026-03-06'
activities:
- id: gomodel:67c10cc400000238/67c10cc400000254
  enabled_by:
    type: EnabledByGeneProductAssociation
    evidence:
    - term: ECO:0000269
      reference: PMID:32499408
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2026-03-06'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2026-03-06'
      provided_by:
      - http://www.pombase.org
    term: PomBase:SPAC926.04c
  molecular_function:
    type: MolecularFunctionAssociation
    term: GO:0140662
  occurs_in:
    type: CellularAnatomicalEntityAssociation
    evidence:
    - term: ECO:0007005
      reference: PMID:16823372
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-03-03'
        provided_by:
        - http://www.pombase.org
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN000163629
      - dictyBase:DDB_G0267400
      - UniProtKB:P11501
      - UniProtKB:P08238
      - UniProtKB:P07900
      - UniProtKB:P40292
      - MGI:MGI:96250
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-03-03'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-03-03'
      provided_by:
      - http://www.pombase.org
    term: GO:0005829
  part_of:
    type: BiologicalProcessAssociation
    evidence:
    - term: ECO:0000304
      reference: PMID:34686329
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-03-03'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-03-03'
      provided_by:
      - http://www.pombase.org
    term: GO:0051083
- id: gomodel:67c10cc400000238/67c10cc400000239
  enabled_by:
    type: EnabledByProteinComplexAssociation
    evidence:
    - term: ECO:0000269
      reference: '

        PMID:34686329'
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-03-03'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-03-03'
      provided_by:
      - http://www.pombase.org
    term: GO:0110078
    has_part:
    - type: ProteinComplexHasPartAssociation
      evidence:
      - term: ECO:0000269
        reference: '

          PMID:34686329'
        provenances:
        - contributor:
          - https://orcid.org/0000-0001-6330-7526
          date: '2025-03-03'
          provided_by:
          - http://www.pombase.org
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-03-03'
        provided_by:
        - http://www.pombase.org
      term: PomBase:SPBC1604.17c
    - type: ProteinComplexHasPartAssociation
      evidence:
      - term: ECO:0000269
        reference: '

          PMID:34686329'
        provenances:
        - contributor:
          - https://orcid.org/0000-0001-6330-7526
          date: '2025-03-03'
          provided_by:
          - http://www.pombase.org
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-03-03'
        provided_by:
        - http://www.pombase.org
      term: PomBase:SPAC458.03
    - type: ProteinComplexHasPartAssociation
      evidence:
      - term: ECO:0000269
        reference: '

          PMID:34686329'
        provenances:
        - contributor:
          - https://orcid.org/0000-0001-6330-7526
          date: '2025-03-03'
          provided_by:
          - http://www.pombase.org
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-03-03'
        provided_by:
        - http://www.pombase.org
      term: PomBase:SPAC1006.02
    - type: ProteinComplexHasPartAssociation
      evidence:
      - term: ECO:0000269
        reference: '

          PMID:34686329'
        provenances:
        - contributor:
          - https://orcid.org/0000-0001-6330-7526
          date: '2025-03-03'
          provided_by:
          - http://www.pombase.org
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-03-03'
        provided_by:
        - http://www.pombase.org
      term: PomBase:SPCC622.13c
  molecular_function:
    type: MolecularFunctionAssociation
    term: GO:0030674
  part_of:
    type: BiologicalProcessAssociation
    evidence:
    - term: ECO:0000269
      reference: '

        PMID:34686329'
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-03-03'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-03-03'
      provided_by:
      - http://www.pombase.org
    term: GO:0051083
  molecular_associations:
  - type: MoleculeAssociation
    evidence:
    - term: ECO:0000269
      reference: '

        PMID:34686329'
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-03-03'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-03-03'
      provided_by:
      - http://www.pombase.org
    predicate: RO:0002233
    molecule: gomodel:67c10cc400000238/67c10cc400000252
  - type: MoleculeAssociation
    evidence:
    - term: ECO:0000269
      reference: '

        PMID:34686329'
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-03-03'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-03-03'
      provided_by:
      - http://www.pombase.org
    predicate: RO:0002233
    molecule: gomodel:67c10cc400000238/67c10cc400000274
  causal_associations:
  - type: CausalAssociation
    evidence:
    - term: ECO:0000269
      reference: '

        PMID:34686329'
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-03-03'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-03-03'
      provided_by:
      - http://www.pombase.org
    predicate: RO:0012009
    downstream_activity: gomodel:67c10cc400000238/67c10cc400000254
  - type: CausalAssociation
    evidence:
    - term: ECO:0000269
      reference: '

        PMID:34686329'
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-03-03'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-03-03'
      provided_by:
      - http://www.pombase.org
    predicate: RO:0012009
    downstream_activity: gomodel:67c10cc400000238/67c10cc400000254
molecules:
- id: gomodel:67c10cc400000238/67c10cc400000252
  term: PomBase:SPAC926.04c
- id: gomodel:67c10cc400000238/67c10cc400000274
  term: PomBase:SPBP16F5.03c
objects:
- id: GO:0030674
  label: protein-macromolecule adaptor activity
  type: gocam:Object
- id: GO:0110078
  label: TTT Hsp90 cochaperone complex
  type: gocam:Object
- id: GO:0051083
  label: '''de novo'' cotranslational protein folding'
  type: gocam:Object
- id: ECO:0000269
  label: experimental evidence used in manual assertion
  type: gocam:Object
- id: PomBase:SPAC1006.02
  label: asa1 Spom
  type: gocam:Object
- id: PomBase:SPAC458.03
  label: tel2 Spom
  type: gocam:Object
- id: PomBase:SPCC622.13c
  label: tti1 Spom
  type: gocam:Object
- id: PomBase:SPBC1604.17c
  label: tti2 Spom
  type: gocam:Object
- id: PomBase:SPAC926.04c
  label: hsp90 Spom
  type: gocam:Object
- id: GO:0140662
  label: ATP-dependent protein folding chaperone
  type: gocam:Object
- id: GO:0005829
  label: cytosol
  type: gocam:Object
- id: ECO:0000304
  label: author statement supported by traceable reference used in manual assertion
  type: gocam:Object
- id: ECO:0007005
  label: high throughput direct assay evidence used in manual assertion
  type: gocam:Object
- id: ECO:0000318
  label: biological aspect of ancestor evidence used in manual assertion
  type: gocam:Object
- id: PomBase:SPBP16F5.03c
  label: tra1 Spom
  type: gocam:Object
provenances:
- contributor:
  - https://orcid.org/0000-0001-6330-7526
  date: '2026-03-06'
  provided_by:
  - http://www.pombase.org
