id: gomodel:67e5e74400003073
title: mitochondrial cytochrome c oxidase assembly  (GO:0033617)
taxon: NCBITaxon:4896
status: production
date_modified: '2025-12-01'
activities:
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      - UniProtKB:Q6UWS5
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-04-21'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-04-21'
      provided_by:
      - http://www.pombase.org
    term: GO:0005739
  part_of:
    type: BiologicalProcessAssociation
    evidence:
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN001999899
      - SGD:S000000860
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-04-21'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-04-21'
      provided_by:
      - http://www.pombase.org
    term: GO:0033617
  molecular_associations:
  - type: MoleculeAssociation
    evidence: []
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-04-21'
      provided_by:
      - http://www.pombase.org
    predicate: RO:0002233
    molecule: gomodel:67e5e74400003073/67f85f2b00002730
  causal_associations:
  - type: CausalAssociation
    evidence: []
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-04-25'
      provided_by:
      - http://www.pombase.org
    predicate: RO:0012009
    downstream_activity: gomodel:67e5e74400003073/67f85f2b00002752
  - type: CausalAssociation
    evidence: []
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-04-25'
      provided_by:
      - http://www.pombase.org
    predicate: RO:0012009
    downstream_activity: gomodel:67e5e74400003073/67e5e74400003080
  - type: CausalAssociation
    evidence: []
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-04-24'
      provided_by:
      - http://www.pombase.org
    predicate: RO:0012009
    downstream_activity: gomodel:67e5e74400003073/67f85f2b00002715
  - type: CausalAssociation
    evidence: []
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-04-25'
      provided_by:
      - http://www.pombase.org
    predicate: RO:0012009
    downstream_activity: gomodel:67e5e74400003073/67e5e74400003087
- id: gomodel:67e5e74400003073/67e5e74400003074
  enabled_by:
    type: EnabledByGeneProductAssociation
    evidence:
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN000423136
      - UniProtKB:Q14061
      - UniProtKB:P81045
      - TAIR:locus:2037072
      - SGD:S000003932
      - TAIR:locus:505006350
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-04-06'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-04-06'
      provided_by:
      - http://www.pombase.org
    term: PomBase:SPBC26H8.14c
  molecular_function:
    type: MolecularFunctionAssociation
    term: GO:0016531
  part_of:
    type: BiologicalProcessAssociation
    evidence: []
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-04-06'
      provided_by:
      - http://www.pombase.org
    term: GO:0033617
  causal_associations:
  - type: CausalAssociation
    evidence:
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN000423136
      - UniProtKB:Q14061
      - UniProtKB:P81045
      - TAIR:locus:2037072
      - SGD:S000003932
      - TAIR:locus:505006350
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-04-06'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-04-06'
      provided_by:
      - http://www.pombase.org
    predicate: RO:0002413
    downstream_activity: gomodel:67e5e74400003073/67e5e74400003087
  - type: CausalAssociation
    evidence:
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN000423136
      - UniProtKB:Q14061
      - UniProtKB:P81045
      - TAIR:locus:2037072
      - SGD:S000003932
      - TAIR:locus:505006350
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-04-06'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-04-06'
      provided_by:
      - http://www.pombase.org
    predicate: RO:0002413
    downstream_activity: gomodel:67e5e74400003073/67e5e74400003098
  - type: CausalAssociation
    evidence:
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN000423136
      - UniProtKB:Q14061
      - UniProtKB:P81045
      - TAIR:locus:2037072
      - SGD:S000003932
      - TAIR:locus:505006350
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-04-06'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-04-06'
      provided_by:
      - http://www.pombase.org
    predicate: RO:0002413
    downstream_activity: gomodel:67e5e74400003073/67e5e74400003080
  - type: CausalAssociation
    evidence:
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN000423136
      - UniProtKB:Q14061
      - UniProtKB:P81045
      - TAIR:locus:2037072
      - SGD:S000003932
      - TAIR:locus:505006350
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-04-06'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-04-06'
      provided_by:
      - http://www.pombase.org
    predicate: RO:0002413
    downstream_activity: gomodel:67e5e74400003073/67e5e74400003080
  - type: CausalAssociation
    evidence:
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN000423136
      - UniProtKB:Q14061
      - UniProtKB:P81045
      - TAIR:locus:2037072
      - SGD:S000003932
      - TAIR:locus:505006350
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-04-06'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-04-06'
      provided_by:
      - http://www.pombase.org
    predicate: RO:0002413
    downstream_activity: gomodel:67e5e74400003073/67e5e74400003087
molecules:
- id: gomodel:67e5e74400003073/67e5e74400003108
  term: PomBase:SPMIT.01
- id: gomodel:67e5e74400003073/67f85f2b00002730
  term: PomBase:SPAC22E12.10c
- id: gomodel:67e5e74400003073/67e5e74400003123
  term: PomBase:SPMIT.11
- id: gomodel:67e5e74400003073/67f85f2b00002664
  term: PomBase:SPMIT.01
- id: gomodel:67e5e74400003073/67e5e74400003107
  term: PomBase:SPMIT.01
- id: gomodel:67e5e74400003073/67f85f2b00004960
  term: PomBase:SPMIT.01
- id: gomodel:67e5e74400003073/67e5e74400003181
  term: PomBase:SPMIT.11
- id: gomodel:67e5e74400003073/67f85f2b00002668
  term: PomBase:SPMIT.01
- id: gomodel:67e5e74400003073/67e5e74400003184
  term: PomBase:SPMIT.11
- id: gomodel:67e5e74400003073/680ad14200000029
  term: PomBase:SPMIT.01
- id: gomodel:67e5e74400003073/67e5e74400003149
  term: PomBase:SPMIT.11
- id: gomodel:67e5e74400003073/67e5e74400003138
  term: PomBase:SPMIT.01
- id: gomodel:67e5e74400003073/67f85f2b00002665
  term: PomBase:SPMIT.01
objects:
- id: GO:0016531
  label: copper chaperone activity
  type: gocam:Object
- id: PomBase:SPBC26H8.14c
  label: cox17 Spom
  type: gocam:Object
- id: ECO:0000318
  label: biological aspect of ancestor evidence used in manual assertion
  type: gocam:Object
- id: GO:0033617
  label: mitochondrial respiratory chain complex IV assembly
  type: gocam:Object
- id: PomBase:SPAC1420.04c
  label: cox1101 Spom
  type: gocam:Object
- id: ECO:0000250
  label: sequence similarity evidence used in manual assertion
  type: gocam:Object
- id: GO:0005743
  label: mitochondrial inner membrane
  type: gocam:Object
- id: ECO:0000314
  label: direct assay evidence used in manual assertion
  type: gocam:Object
- id: PomBase:SPAC19B12.13
  label: cox1102 Spom
  type: gocam:Object
- id: PomBase:SPBC119.06
  label: sco1 Spom
  type: gocam:Object
- id: ECO:0000266
  label: sequence orthology evidence used in manual assertion
  type: gocam:Object
- id: PomBase:SPMIT.01
  label: cox1 Spom
  type: gocam:Object
- id: GO:0004129
  label: cytochrome-c oxidase activity
  type: gocam:Object
- id: GO:0045277
  label: respiratory chain complex IV
  type: gocam:Object
- id: GO:0006123
  label: mitochondrial electron transport, cytochrome c to oxygen
  type: gocam:Object
- id: GO:0140597
  label: protein carrier activity
  type: gocam:Object
- id: PomBase:SPBC25H2.18
  label: cox20 Spom
  type: gocam:Object
- id: PomBase:SPMIT.11
  label: cox2 Spom
  type: gocam:Object
- id: GO:0032977
  label: membrane insertase activity
  type: gocam:Object
- id: PomBase:SPAC9G1.04
  label: oxa101 Spom
  type: gocam:Object
- id: GO:0032979
  label: protein insertion into mitochondrial inner membrane from matrix
  type: gocam:Object
- id: GO:0003674
  label: molecular_function
  type: gocam:Object
- id: PomBase:SPAC1486.08
  label: cox16 Spom
  type: gocam:Object
- id: PomBase:SPCC4B3.20
  label: cmc1 Spom
  type: gocam:Object
- id: PomBase:SPBC21D10.07
  label: cmc2 Spom
  type: gocam:Object
- id: GO:0031314
  label: extrinsic component of mitochondrial inner membrane
  type: gocam:Object
- id: GO:0005758
  label: mitochondrial intermembrane space
  type: gocam:Object
- id: PomBase:SPCC1442.15c
  label: cox18 Spom
  type: gocam:Object
- id: ECO:0000316
  label: genetic interaction evidence used in manual assertion
  type: gocam:Object
- id: PomBase:SPBC24C6.13
  label: coa6 Spom
  type: gocam:Object
- id: PomBase:SPAC25B8.04c
  label: mss51 Spom
  type: gocam:Object
- id: ECO:0000307
  label: no evidence data found used in manual assertion
  type: gocam:Object
- id: ECO:0000315
  label: mutant phenotype evidence used in manual assertion
  type: gocam:Object
- id: PomBase:SPAC1B3.21
  label: coa3 Spom
  type: gocam:Object
- id: GO:0099617
  label: matrix side of mitochondrial inner membrane
  type: gocam:Object
- id: GO:0030674
  label: protein-macromolecule adaptor activity
  type: gocam:Object
- id: PomBase:SPBC16E9.03c
  label: coa1 Spom
  type: gocam:Object
- id: PomBase:SPBC16A3.16
  label: coa5 Spom
  type: gocam:Object
- id: PomBase:SPAC25B8.07c
  label: rcf1 Spom
  type: gocam:Object
- id: GO:0060090
  label: molecular adaptor activity
  type: gocam:Object
- id: PomBase:SPBC1604.25
  label: pet117 Spom
  type: gocam:Object
- id: GO:0005739
  label: mitochondrion
  type: gocam:Object
- id: GO:0120547
  label: heme A synthase activity
  type: gocam:Object
- id: PomBase:SPAC22E12.10c
  label: etp1 Spom
  type: gocam:Object
- id: GO:0006784
  label: heme A biosynthetic process
  type: gocam:Object
- id: PomBase:SPBC1215.01
  label: shy1 Spom
  type: gocam:Object
- id: ECO:0000269
  label: experimental evidence used in manual assertion
  type: gocam:Object
- id: PomBase:SPAC15A10.17
  label: coa2 Spom
  type: gocam:Object
- id: ECO:0000305
  label: curator inference used in manual assertion
  type: gocam:Object
- id: PomBase:SPCC757.15
  label: cox14 Spom
  type: gocam:Object
- id: PomBase:SPCC550.01c
  label: coa4 Spom
  type: gocam:Object
- id: GO:0005507
  label: copper ion binding
  type: gocam:Object
- id: PomBase:SPCC1672.04c
  label: cox19 Spom
  type: gocam:Object
- id: PomBase:SPBC3H7.08c
  label: mra2 Spom
  type: gocam:Object
- id: PomBase:SPAC1565.01
  label: rcf2 Spom
  type: gocam:Object
- id: PomBase:SPBP4H10.03
  label: oxa102 Spom
  type: gocam:Object
- id: GO:0006119
  label: oxidative phosphorylation
  type: gocam:Object
- id: ECO:0000304
  label: author statement supported by traceable reference used in manual assertion
  type: gocam:Object
provenances:
- contributor:
  - https://orcid.org/0000-0001-6330-7526
  date: '2025-12-01'
  provided_by:
  - http://www.pombase.org
