id: gomodel:6690711d00001545
title: L-serine biosynthetic process (GO:0006564), L-cysteine biosynthetic process
  (GO:0019344)
taxon: NCBITaxon:4896
status: production
date_modified: '2026-07-26'
comments:
- 'Automated change 2026-02-26: GO:0006535 replaced by GO:0019344'
- 'basic pathway https://www.researchgate.net/publication/6852717_A_Peroxisomal_Glutathione_Transferase_of_Saccharomyces_cerevisiae_Is_Functionally_Related_to_Sulfur_Amino_Acid_Metabolism/figures?lo=1

  '
activities:
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      with_objects:
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        date: '2025-03-14'
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    term: PomBase:SPAC17G6.15c
  molecular_function:
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    term: GO:0015194
  occurs_in:
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    evidence:
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    term: GO:0005743
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    term: PomBase:SPBC106.17c
  molecular_function:
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    term: GO:0160210
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    term: PomBase:SPCC364.07
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      - https://orcid.org/0000-0001-6330-7526
      date: '2025-03-17'
      provided_by:
      - http://www.pombase.org
    term: GO:0005759
- id: gomodel:6690711d00001545/67f85f2b00003576
  term: CHEBI:29985
  located_in:
    type: CellularAnatomicalEntityAssociation
    evidence: []
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-04-23'
      provided_by:
      - http://www.pombase.org
    term: GO:0005829
- id: gomodel:6690711d00001545/67c10cc400005456
  term: CHEBI:57524
  located_in:
    type: CellularAnatomicalEntityAssociation
    evidence: []
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-03-17'
      provided_by:
      - http://www.pombase.org
    term: GO:0005829
- id: gomodel:6690711d00001545/67e5e74400000232
  term: CHEBI:18110
  located_in:
    type: CellularAnatomicalEntityAssociation
    evidence: []
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-04-23'
      provided_by:
      - http://www.pombase.org
    term: GO:0005829
- id: gomodel:6690711d00001545/689e7a5d00005542
  term: PomBase:SPMITTRNASER.02
- id: gomodel:6690711d00001545/67f85f2b00003581
  term: CHEBI:29162
- id: gomodel:6690711d00001545/6690711d00001569
  term: CHEBI:33384
  located_in:
    type: CellularAnatomicalEntityAssociation
    evidence: []
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-03-14'
      provided_by:
      - http://www.pombase.org
    term: GO:0005829
- id: gomodel:6690711d00001545/689e7a5d00005541
  term: PomBase:SPMITTRNASER.01
objects:
- id: ECO:0000303
  label: author statement without traceable support used in manual assertion
  type: gocam:Object
- id: GO:0004617
  label: phosphoglycerate dehydrogenase activity
  type: gocam:Object
- id: PomBase:SPCC364.07
  label: ser3 Spom
  type: gocam:Object
- id: GO:0006564
  label: L-serine biosynthetic process
  type: gocam:Object
- id: GO:0005829
  label: cytosol
  type: gocam:Object
- id: ECO:0000250
  label: sequence similarity evidence used in manual assertion
  type: gocam:Object
- id: ECO:0007005
  label: high throughput direct assay evidence used in manual assertion
  type: gocam:Object
- id: GO:0004648
  label: O-phospho-L-serine:2-oxoglutarate transaminase activity
  type: gocam:Object
- id: PomBase:SPAC1F12.07
  label: ser1 Spom
  type: gocam:Object
- id: ECO:0000318
  label: biological aspect of ancestor evidence used in manual assertion
  type: gocam:Object
- id: GO:0036424
  label: L-phosphoserine phosphatase activity
  type: gocam:Object
- id: PomBase:SPBC3H7.07c
  label: ser2 Spom
  type: gocam:Object
- id: ECO:0000305
  label: curator inference used in manual assertion
  type: gocam:Object
- id: CHEBI:33384
  label: L-serine zwitterion
  type: gocam:Object
- id: CHEBI:58272
  label: 3-phosphonato-D-glycerate(3-)
  type: gocam:Object
- id: GO:0015194
  label: L-serine transmembrane transporter activity
  type: gocam:Object
- id: PomBase:SPAC17G6.15c
  label: fsf1 Spom
  type: gocam:Object
- id: GO:0140300
  label: serine import into mitochondrion
  type: gocam:Object
- id: GO:0005743
  label: mitochondrial inner membrane
  type: gocam:Object
- id: ECO:0000314
  label: direct assay evidence used in manual assertion
  type: gocam:Object
- id: GO:0005759
  label: mitochondrial matrix
  type: gocam:Object
- id: CHEBI:16810
  label: 2-oxoglutarate(2-)
  type: gocam:Object
- id: CHEBI:57524
  label: O-phosphonato-L-serine(2-)
  type: gocam:Object
- id: GO:0005739
  label: mitochondrion
  type: gocam:Object
- id: CHEBI:18110
  label: 3-phosphonatooxypyruvate(3-)
  type: gocam:Object
- id: GO:0004828
  label: serine-tRNA ligase activity
  type: gocam:Object
- id: PomBase:SPAC25B8.06c
  label: dia4 Spom
  type: gocam:Object
- id: GO:0070158
  label: mitochondrial seryl-tRNA aminoacylation
  type: gocam:Object
- id: GO:0004817
  label: cysteine-tRNA ligase activity
  type: gocam:Object
- id: PomBase:SPAC29E6.06c
  label: SPAC29E6.06c Spom
  type: gocam:Object
- id: GO:0006423
  label: cysteinyl-tRNA aminoacylation
  type: gocam:Object
- id: CHEBI:29985
  label: L-glutamate(1-)
  type: gocam:Object
- id: CHEBI:29152
  label: Cys-tRNA(Cys)
  type: gocam:Object
- id: PomBase:SPMITTRNACYS.01
  label: SPMITTRNACYS.01 Spom
  type: gocam:Object
- id: CHEBI:29162
  label: Ser-tRNA(Ser)
  type: gocam:Object
- id: GO:0004124
  label: cysteine synthase activity
  type: gocam:Object
- id: PomBase:SPBC36.04
  label: cys11 Spom
  type: gocam:Object
- id: GO:0019344
  label: L-cysteine biosynthetic process
  type: gocam:Object
- id: ECO:0000315
  label: mutant phenotype evidence used in manual assertion
  type: gocam:Object
- id: GO:0160210
  label: L-serine O-succinyltransferase activity
  type: gocam:Object
- id: PomBase:SPBC106.17c
  label: cys2 Spom
  type: gocam:Object
- id: CHEBI:134286
  label: O-succinyl-L-serine
  type: gocam:Object
- id: CHEBI:16136
  label: hydrogen sulfide
  type: gocam:Object
- id: CHEBI:35235
  label: L-cysteine zwitterion
  type: gocam:Object
- id: CHEBI:26806
  label: succinate
  type: gocam:Object
- id: PomBase:SPMITTRNASER.01
  label: SPMITTRNASER.01 Spom
  type: gocam:Object
- id: PomBase:SPMITTRNASER.02
  label: SPMITTRNASER.02 Spom
  type: gocam:Object
- id: CHEBI:35247
  label: D-serine zwitterion
  type: gocam:Object
- id: ECO:0000501
  label: evidence used in automatic assertion
  type: gocam:Object
- id: GO:0008721
  label: D-serine ammonia-lyase activity
  type: gocam:Object
- id: PomBase:SPAC1039.06
  label: SPAC1039.06 Spom
  type: gocam:Object
- id: GO:0036088
  label: D-serine catabolic process
  type: gocam:Object
- id: GO:0030378
  label: serine racemase activity
  type: gocam:Object
- id: PomBase:SPCC320.14
  label: sry1 Spom
  type: gocam:Object
provenances:
- contributor:
  - https://orcid.org/0000-0001-6330-7526
  date: '2026-07-26'
  provided_by:
  - http://www.pombase.org
