id: gomodel:66c7d41500000841
title: ' siroheme biosynthetic process (GO:0019354) and heme biosynthetic process
  (GO:0006783)'
taxon: NCBITaxon:4896
status: production
date_modified: '2026-07-19'
activities:
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    term: PomBase:SPAC1F5.07c
  molecular_function:
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      - ZFIN:ZDB-GENE-000208-18
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    predicate: RO:0002234
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    predicate: RO:0002233
    molecule: gomodel:66c7d41500000841/66c7d41500000877
- id: gomodel:66c7d41500000841/67c10cc400004685
  enabled_by:
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    evidence:
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      reference: GO_REF:0000015
      provenances:
      - contributor:
        - https://orcid.org/0009-0003-9059-1333
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      provided_by:
      - http://www.pombase.org
    term: PomBase:SPBC17A3.02
  molecular_function:
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    term: GO:0003674
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    evidence:
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      provided_by:
      - http://www.pombase.org
    term: GO:0005739
  part_of:
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    evidence:
    - term: ECO:0000303
      reference: PMID:25157825
      provenances:
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        provided_by:
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      date: '2025-03-13'
      provided_by:
      - http://www.pombase.org
    term: GO:0006783
  molecular_associations:
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      provenances:
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    predicate: RO:0002233
    molecule: gomodel:66c7d41500000841/69d8496c00005659
  - type: MoleculeAssociation
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        provided_by:
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    predicate: RO:0002234
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    term: PomBase:SPAC4D7.06c
  molecular_function:
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    term: GO:0043115
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    evidence:
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      provided_by:
      - http://www.pombase.org
    term: GO:0005829
  part_of:
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    evidence:
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      reference: GO_REF:0000033
      with_objects:
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    provenances:
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      date: '2024-09-02'
      provided_by:
      - http://www.pombase.org
    term: GO:0019354
  molecular_associations:
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    predicate: RO:0002233
    molecule: gomodel:66c7d41500000841/69d8496c00005647
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    predicate: RO:0002234
    molecule: gomodel:66c7d41500000841/69d8496c00005651
molecules:
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    term: GO:0005829
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    term: GO:0005829
- id: gomodel:66c7d41500000841/689e7a5d00004765
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    term: GO:0005759
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    term: GO:0005829
- id: gomodel:66c7d41500000841/66c7d41500000932
  term: CHEBI:60530
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      - http://www.pombase.org
    term: GO:0005759
- id: gomodel:66c7d41500000841/66c7d41500000959
  term: CHEBI:60052
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      - http://www.pombase.org
    term: GO:0005829
- id: gomodel:66c7d41500000841/67c10cc400007271
  term: CHEBI:57856
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      - http://www.pombase.org
    term: GO:0005829
- id: gomodel:66c7d41500000841/69d8496c00005628
  term: CHEBI:57305
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    type: CellularAnatomicalEntityAssociation
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      - http://www.pombase.org
    term: GO:0005829
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  term: CHEBI:29033
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    type: CellularAnatomicalEntityAssociation
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      - http://www.pombase.org
    term: GO:0005759
- id: gomodel:66c7d41500000841/69d8496c00005632
  term: CHEBI:356416
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    type: CellularAnatomicalEntityAssociation
    evidence: []
    provenances:
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      - http://www.pombase.org
    term: GO:0005829
- id: gomodel:66c7d41500000841/69d8496c00005651
  term: CHEBI:58351
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    type: CellularAnatomicalEntityAssociation
    evidence: []
    provenances:
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      - http://www.pombase.org
    term: GO:0005829
- id: gomodel:66c7d41500000841/69d8496c00005640
  term: CHEBI:57845
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    type: CellularAnatomicalEntityAssociation
    evidence: []
    provenances:
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      - http://www.pombase.org
    term: GO:0005829
- id: gomodel:66c7d41500000841/67c10cc400007268
  term: CHEBI:59789
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    type: CellularAnatomicalEntityAssociation
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    provenances:
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      - http://www.pombase.org
    term: GO:0005829
- id: gomodel:66c7d41500000841/67c10cc400007282
  term: CHEBI:16240
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    type: CellularAnatomicalEntityAssociation
    evidence: []
    provenances:
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      - https://orcid.org/0009-0003-9059-1333
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      - http://www.pombase.org
    term: GO:0005759
- id: gomodel:66c7d41500000841/66c7d41500000943
  term: CHEBI:61715
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    type: CellularAnatomicalEntityAssociation
    evidence: []
    provenances:
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      - https://orcid.org/0009-0003-9059-1333
      date: '2025-03-13'
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      - http://www.pombase.org
    term: GO:0005759
- id: gomodel:66c7d41500000841/66c7d41500000851
  term: CHEBI:57305
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    type: CellularAnatomicalEntityAssociation
    evidence: []
    provenances:
    - contributor:
      - https://orcid.org/0009-0003-9059-1333
      date: '2025-03-13'
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      - http://www.pombase.org
    term: GO:0005759
- id: gomodel:66c7d41500000841/67c10cc400004617
  term: CHEBI:57292
  located_in:
    type: CellularAnatomicalEntityAssociation
    evidence: []
    provenances:
    - contributor:
      - https://orcid.org/0009-0003-9059-1333
      date: '2025-03-13'
      provided_by:
      - http://www.pombase.org
    term: GO:0005759
- id: gomodel:66c7d41500000841/67c10cc400007321
  term: CHEBI:33019
  located_in:
    type: CellularAnatomicalEntityAssociation
    evidence: []
    provenances:
    - contributor:
      - https://orcid.org/0009-0003-9059-1333
      date: '2025-03-21'
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      - http://www.pombase.org
    term: GO:0005759
- id: gomodel:66c7d41500000841/66c7d41500000920
  term: CHEBI:60344
  located_in:
    type: CellularAnatomicalEntityAssociation
    evidence: []
    provenances:
    - contributor:
      - https://orcid.org/0009-0003-9059-1333
      date: '2025-03-13'
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      - http://www.pombase.org
    term: GO:0005759
- id: gomodel:66c7d41500000841/69d8496c00005636
  term: CHEBI:58126
  located_in:
    type: CellularAnatomicalEntityAssociation
    evidence: []
    provenances:
    - contributor:
      - https://orcid.org/0009-0003-9059-1333
      date: '2026-04-23'
      provided_by:
      - http://www.pombase.org
    term: GO:0005829
- id: gomodel:66c7d41500000841/689e7a5d00004792
  term: CHEBI:57501
  located_in:
    type: CellularAnatomicalEntityAssociation
    evidence: []
    provenances:
    - contributor:
      - https://orcid.org/0009-0003-9059-1333
      date: '2025-08-26'
      provided_by:
      - http://www.pombase.org
    term: GO:0005759
- id: gomodel:66c7d41500000841/69d8496c00005664
  term: CHEBI:57307
  located_in:
    type: CellularAnatomicalEntityAssociation
    evidence: []
    provenances:
    - contributor:
      - https://orcid.org/0009-0003-9059-1333
      date: '2026-04-23'
      provided_by:
      - http://www.pombase.org
    term: GO:0005759
- id: gomodel:66c7d41500000841/69b3372b00001118
  term: CHEBI:57306
  located_in:
    type: CellularAnatomicalEntityAssociation
    evidence: []
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2026-03-16'
      provided_by:
      - http://www.pombase.org
    term: GO:0005743
- id: gomodel:66c7d41500000841/67c10cc400007256
  term: CHEBI:57287
  located_in:
    type: CellularAnatomicalEntityAssociation
    evidence: []
    provenances:
    - contributor:
      - https://orcid.org/0009-0003-9059-1333
      date: '2025-03-21'
      provided_by:
      - http://www.pombase.org
    term: GO:0005759
objects:
- id: GO:0003870
  label: 5-aminolevulinate synthase activity
  type: gocam:Object
- id: PomBase:SPAC2F3.09
  label: hem1 Spom
  type: gocam:Object
- id: GO:0006783
  label: heme biosynthetic process
  type: gocam:Object
- id: ECO:0000315
  label: mutant phenotype evidence used in manual assertion
  type: gocam:Object
- id: ECO:0000318
  label: biological aspect of ancestor evidence used in manual assertion
  type: gocam:Object
- id: CHEBI:57305
  label: glycine zwitterion
  type: gocam:Object
- id: GO:0004655
  label: porphobilinogen synthase activity
  type: gocam:Object
- id: PomBase:SPAC1805.06c
  label: hem2 Spom
  type: gocam:Object
- id: GO:0004418
  label: hydroxymethylbilane synthase activity
  type: gocam:Object
- id: PomBase:SPAC24B11.13
  label: hem3 Spom
  type: gocam:Object
- id: GO:0004852
  label: uroporphyrinogen-III synthase activity
  type: gocam:Object
- id: PomBase:SPAC31G5.08
  label: hem4 Spom
  type: gocam:Object
- id: CHEBI:57308
  label: uroporphyrinogen III(8-)
  type: gocam:Object
- id: GO:0004853
  label: uroporphyrinogen decarboxylase activity
  type: gocam:Object
- id: PomBase:SPCC4B3.05c
  label: hem12 Spom
  type: gocam:Object
- id: GO:0004851
  label: uroporphyrin-III C-methyltransferase activity
  type: gocam:Object
- id: PomBase:SPCC1739.06c
  label: met1 Spom
  type: gocam:Object
- id: GO:0019354
  label: siroheme biosynthetic process
  type: gocam:Object
- id: GO:0004109
  label: coproporphyrinogen oxidase activity
  type: gocam:Object
- id: PomBase:SPAC222.11
  label: hem13 Spom
  type: gocam:Object
- id: GO:0004729
  label: protoporphyrinogen oxidase activity, oxygen as acceptor
  type: gocam:Object
- id: PomBase:SPAC1F5.07c
  label: hem14 Spom
  type: gocam:Object
- id: ECO:0000305
  label: curator inference used in manual assertion
  type: gocam:Object
- id: GO:0004325
  label: protoporphyrin ferrochelatase activity
  type: gocam:Object
- id: PomBase:SPCC320.09
  label: hem15 Spom
  type: gocam:Object
- id: GO:0034986
  label: iron chaperone activity
  type: gocam:Object
- id: PomBase:SPCC1183.03c
  label: fxn1 Spom
  type: gocam:Object
- id: GO:0005759
  label: mitochondrial matrix
  type: gocam:Object
- id: ECO:0000266
  label: sequence orthology evidence used in manual assertion
  type: gocam:Object
- id: ECO:0000250
  label: sequence similarity evidence used in manual assertion
  type: gocam:Object
- id: CHEBI:60344
  label: ferroheme b(2-)
  type: gocam:Object
- id: GO:0008495
  label: protoheme IX farnesyltransferase activity
  type: gocam:Object
- id: PomBase:SPBC365.02c
  label: cox10 Spom
  type: gocam:Object
- id: GO:0006784
  label: heme A biosynthetic process
  type: gocam:Object
- id: CHEBI:60530
  label: ferroheme o(2-)
  type: gocam:Object
- id: GO:0003958
  label: NADPH-hemoprotein reductase activity
  type: gocam:Object
- id: PomBase:SPAC22E12.10c
  label: etp1 Spom
  type: gocam:Object
- id: CHEBI:61715
  label: ferroheme a(2-)
  type: gocam:Object
- id: GO:0043115
  label: precorrin-2 dehydrogenase activity
  type: gocam:Object
- id: PomBase:SPAC4D7.06c
  label: met8 Spom
  type: gocam:Object
- id: GO:0051266
  label: sirohydrochlorin ferrochelatase activity
  type: gocam:Object
- id: ECO:0000501
  label: evidence used in automatic assertion
  type: gocam:Object
- id: CHEBI:60052
  label: siroheme(8-)
  type: gocam:Object
- id: CHEBI:57292
  label: succinyl-CoA(5-)
  type: gocam:Object
- id: GO:0005829
  label: cytosol
  type: gocam:Object
- id: ECO:0007005
  label: high throughput direct assay evidence used in manual assertion
  type: gocam:Object
- id: GO:0015187
  label: glycine transmembrane transporter activity
  type: gocam:Object
- id: PomBase:SPAC823.10c
  label: hem25 Spom
  type: gocam:Object
- id: GO:1904983
  label: glycine import into mitochondrion
  type: gocam:Object
- id: GO:0005743
  label: mitochondrial inner membrane
  type: gocam:Object
- id: GO:0004149
  label: dihydrolipoyllysine-residue succinyltransferase activity
  type: gocam:Object
- id: PomBase:SPBC776.15c
  label: kgd2 Spom
  type: gocam:Object
- id: GO:0006099
  label: tricarboxylic acid cycle
  type: gocam:Object
- id: GO:0005739
  label: mitochondrion
  type: gocam:Object
- id: ECO:0000269
  label: experimental evidence used in manual assertion
  type: gocam:Object
- id: GO:0140485
  label: 5-aminolevulinic acid transmembrane transporter activity
  type: gocam:Object
- id: PomBase:SPBC725.10
  label: tsp0 Spom
  type: gocam:Object
- id: GO:0005741
  label: mitochondrial outer membrane
  type: gocam:Object
- id: ECO:0000304
  label: author statement supported by traceable reference used in manual assertion
  type: gocam:Object
- id: GO:0003674
  label: molecular_function
  type: gocam:Object
- id: PomBase:SPBC17A3.02
  label: aim19 Spom
  type: gocam:Object
- id: ECO:0000307
  label: no evidence data found used in manual assertion
  type: gocam:Object
- id: ECO:0000303
  label: author statement without traceable support used in manual assertion
  type: gocam:Object
- id: PomBase:SPAP14E8.05c
  label: SPAP14E8.05c Spom
  type: gocam:Object
- id: CHEBI:57287
  label: coenzyme A(4-)
  type: gocam:Object
- id: CHEBI:59789
  label: S-adenosyl-L-methionine zwitterion
  type: gocam:Object
- id: CHEBI:57856
  label: S-adenosyl-L-homocysteine zwitterion
  type: gocam:Object
- id: CHEBI:29033
  label: iron(2+)
  type: gocam:Object
- id: CHEBI:16240
  label: hydrogen peroxide
  type: gocam:Object
- id: GO:0015093
  label: ferrous iron transmembrane transporter activity
  type: gocam:Object
- id: PomBase:SPAC8C9.12c
  label: mrs3 Spom
  type: gocam:Object
- id: GO:0048250
  label: iron import into the mitochondrion
  type: gocam:Object
- id: GO:0005381
  label: iron ion transmembrane transporter activity
  type: gocam:Object
- id: PomBase:SPAC4G8.08
  label: mrs4 Spom
  type: gocam:Object
- id: CHEBI:175763
  label: 2-trans,6-trans-farnesyl diphosphate(3-)
  type: gocam:Object
- id: CHEBI:33019
  label: diphosphate(3-)
  type: gocam:Object
- id: ECO:0000314
  label: direct assay evidence used in manual assertion
  type: gocam:Object
- id: PomBase:SPAC4G9.20c
  label: ymc1 Spom
  type: gocam:Object
- id: CHEBI:356416
  label: 5-ammoniolevulinate
  type: gocam:Object
- id: GO:0042286
  label: glutamate-1-semialdehyde 2,1-aminomutase activity
  type: gocam:Object
- id: PomBase:SPCC417.11c
  label: SPCC417.11c Spom
  type: gocam:Object
- id: GO:0033013
  label: tetrapyrrole metabolic process
  type: gocam:Object
- id: ECO:0000255
  label: match to sequence model evidence used in manual assertion
  type: gocam:Object
- id: CHEBI:57501
  label: (S)-4-amino-5-oxopentanoic acid zwitterion
  type: gocam:Object
- id: GO:0099617
  label: matrix side of mitochondrial inner membrane
  type: gocam:Object
- id: CHEBI:57306
  label: protoporphyrin(2-)
  type: gocam:Object
- id: GO:0061840
  label: high-affinity ferrous iron transmembrane transporter activity
  type: gocam:Object
- id: PomBase:SPAC1F7.07c
  label: fip1 Spom
  type: gocam:Object
- id: GO:0033573
  label: high-affinity iron permease complex
  type: gocam:Object
- id: GO:0033215
  label: reductive iron assimilation
  type: gocam:Object
- id: GO:0005886
  label: plasma membrane
  type: gocam:Object
- id: ECO:0000316
  label: genetic interaction evidence used in manual assertion
  type: gocam:Object
- id: CHEBI:58126
  label: porphobilinogen(1-)
  type: gocam:Object
- id: CHEBI:57845
  label: preuroporphyrinogen(8-)
  type: gocam:Object
- id: CHEBI:28938
  label: ammonium
  type: gocam:Object
- id: CHEBI:58827
  label: precorrin-2(7-)
  type: gocam:Object
- id: CHEBI:58351
  label: sirohydrochlorin(8-)
  type: gocam:Object
- id: CHEBI:57309
  label: coproporphyrinogen III(4-)
  type: gocam:Object
- id: CHEBI:57307
  label: protoporphyrinogen(2-)
  type: gocam:Object
provenances:
- contributor:
  - https://orcid.org/0000-0001-6330-7526
  - https://orcid.org/0009-0003-9059-1333
  date: '2026-07-19'
  provided_by:
  - http://www.pombase.org
