id: gomodel:67e5e74400004366
title: tRNA modification (GO:0006400) (nuclear/cytosolic)
taxon: NCBITaxon:4896
status: production
date_modified: '2025-10-25'
activities:
- id: gomodel:67e5e74400004366/67e5e74400004416
  enabled_by:
    type: EnabledByGeneProductAssociation
    evidence:
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN000317053
      - dictyBase:DDB_G0292448
      - MGI:MGI:1914917
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-04-10'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-04-10'
      provided_by:
      - http://www.pombase.org
    term: PomBase:SPAC13D6.03c
  molecular_function:
    type: MolecularFunctionAssociation
    term: GO:0106335
  part_of:
    type: BiologicalProcessAssociation
    evidence:
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN000317053
      - MGI:MGI:1914917
      - SGD:S000004476
      - TAIR:locus:2035947
      - FB:FBgn0034748
      - dictyBase:DDB_G0292448
      - UniProtKB:Q96BT7
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-04-10'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-04-10'
      provided_by:
      - http://www.pombase.org
    term: GO:0002098
  molecular_associations:
  - type: MoleculeAssociation
    evidence:
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN000317053
      - dictyBase:DDB_G0292448
      - MGI:MGI:1914917
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-04-10'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-04-10'
      provided_by:
      - http://www.pombase.org
    predicate: RO:0002233
    molecule: gomodel:67e5e74400004366/67e5e74400004415
  - type: MoleculeAssociation
    evidence: []
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-04-10'
      provided_by:
      - http://www.pombase.org
    predicate: RO:0002234
    molecule: gomodel:67e5e74400004366/67e5e74400004423
- id: gomodel:67e5e74400004366/67e5e74400004387
  enabled_by:
    type: EnabledByGeneProductAssociation
    evidence:
    - term: ECO:0000315
      reference: PMID:32841241
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-04-10'
        provided_by:
        - http://www.pombase.org
    - term: ECO:0000315
      reference: PMID:32841241
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-04-10'
        provided_by:
        - http://www.pombase.org
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN000602515
      - UniProtKB:Q9UBP6
      - UniProtKB:P0A8I5
      - SGD:S000002360
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-04-10'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-04-10'
      provided_by:
      - http://www.pombase.org
    term: PomBase:SPCPB16A4.04c
  molecular_function:
    type: MolecularFunctionAssociation
    term: GO:0008176
  occurs_in:
    type: CellularAnatomicalEntityAssociation
    evidence:
    - term: ECO:0000305
      reference: GO_REF:0000111
      with_objects:
      - GO:0008176
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-04-11'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-04-11'
      provided_by:
      - http://www.pombase.org
    term: GO:0005634
  part_of:
    type: BiologicalProcessAssociation
    evidence:
    - term: ECO:0000315
      reference: PMID:32841241
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-04-10'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-04-10'
      provided_by:
      - http://www.pombase.org
    term: GO:0106004
  molecular_associations:
  - type: MoleculeAssociation
    evidence: []
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-04-10'
      provided_by:
      - http://www.pombase.org
    predicate: RO:0002233
    molecule: gomodel:67e5e74400004366/67e5e74400004396
  - type: MoleculeAssociation
    evidence: []
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-04-10'
      provided_by:
      - http://www.pombase.org
    predicate: RO:0002234
    molecule: gomodel:67e5e74400004366/67e5e74400004395
- id: gomodel:67e5e74400004366/67e5e74400004367
  enabled_by:
    type: EnabledByGeneProductAssociation
    evidence:
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN000100786
      - UniProtKB:P76562
      - UniProtKB:Q5JHC6
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-04-10'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-04-10'
      provided_by:
      - http://www.pombase.org
    term: PomBase:SPAC20G8.09c
  molecular_function:
    type: MolecularFunctionAssociation
    term: GO:0051392
  occurs_in:
    type: CellularAnatomicalEntityAssociation
    evidence:
    - term: ECO:0007005
      reference: PMID:16823372
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-04-10'
        provided_by:
        - http://www.pombase.org
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN000100787
      - UniProtKB:Q582B4
      - UniProtKB:Q9H0A0
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-04-10'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-04-10'
      provided_by:
      - http://www.pombase.org
    term: GO:0005730
  molecular_associations:
  - type: MoleculeAssociation
    evidence: []
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-04-10'
      provided_by:
      - http://www.pombase.org
    predicate: RO:0002233
    molecule: gomodel:67e5e74400004366/67e5e74400004385
  - type: MoleculeAssociation
    evidence: []
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-04-10'
      provided_by:
      - http://www.pombase.org
    predicate: RO:0002233
    molecule: gomodel:67e5e74400004366/67e5e74400004386
- id: gomodel:67e5e74400004366/67e5e74400004373
  enabled_by:
    type: EnabledByGeneProductAssociation
    evidence:
    - term: ECO:0000315
      reference: PMID:38295128
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-04-10'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-04-10'
      provided_by:
      - http://www.pombase.org
    term: PomBase:SPBC25H2.10c
  molecular_function:
    type: MolecularFunctionAssociation
    term: GO:0180014
  part_of:
    type: BiologicalProcessAssociation
    evidence:
    - term: ECO:0000250
      reference: GO_REF:0000024
      with_objects:
      - UniProtKB:P53072
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-04-10'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-04-10'
      provided_by:
      - http://www.pombase.org
    term: GO:0051391
  molecular_associations:
  - type: MoleculeAssociation
    evidence: []
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-04-10'
      provided_by:
      - http://www.pombase.org
    predicate: RO:0002233
    molecule: gomodel:67e5e74400004366/67e5e74400004384
  - type: MoleculeAssociation
    evidence: []
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-04-10'
      provided_by:
      - http://www.pombase.org
    predicate: RO:0002233
    molecule: gomodel:67e5e74400004366/67e5e74400004383
  causal_associations:
  - type: CausalAssociation
    evidence:
    - term: ECO:0000315
      reference: PMID:38295128
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-04-10'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-04-10'
      provided_by:
      - http://www.pombase.org
    predicate: RO:0012009
    downstream_activity: gomodel:67e5e74400004366/67e5e74400004367
- id: gomodel:67e5e74400004366/67e5e74400004397
  enabled_by:
    type: EnabledByGeneProductAssociation
    evidence:
    - term: ECO:0000307
      reference: GO_REF:0000015
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-04-10'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-04-10'
      provided_by:
      - http://www.pombase.org
    term: PomBase:SPCC18.13
  molecular_function:
    type: MolecularFunctionAssociation
    term: GO:0003674
  occurs_in:
    type: CellularAnatomicalEntityAssociation
    evidence:
    - term: ECO:0000305
      reference: GO_REF:0000111
      with_objects:
      - GO:0106004
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-04-11'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-04-11'
      provided_by:
      - http://www.pombase.org
    term: GO:0005634
  part_of:
    type: BiologicalProcessAssociation
    evidence:
    - term: ECO:0000266
      reference: GO_REF:0000024
      with_objects:
      - SGD:S000002360
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-04-10'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-04-10'
      provided_by:
      - http://www.pombase.org
    term: GO:0106004
  causal_associations:
  - type: CausalAssociation
    evidence:
    - term: ECO:0000307
      reference: GO_REF:0000015
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-04-10'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-04-10'
      provided_by:
      - http://www.pombase.org
    predicate: RO:0012009
    downstream_activity: gomodel:67e5e74400004366/67e5e74400004387
- id: gomodel:67e5e74400004366/67e5e74400004403
  enabled_by:
    type: EnabledByProteinComplexAssociation
    evidence:
    - term: ECO:0000266
      reference: GO_REF:0000024
      with_objects:
      - UniProtKB:Q9H9T3
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-04-10'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-04-10'
      provided_by:
      - http://www.pombase.org
    term: GO:0033588
    has_part:
    - type: ProteinComplexHasPartAssociation
      evidence: []
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-04-10'
        provided_by:
        - http://www.pombase.org
      term: PomBase:SPBC36.07
    - type: ProteinComplexHasPartAssociation
      evidence: []
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-04-10'
        provided_by:
        - http://www.pombase.org
      term: PomBase:SPCC11E10.06c
    - type: ProteinComplexHasPartAssociation
      evidence: []
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-06-15'
        provided_by:
        - http://www.pombase.org
      term: PomBase:SPBC18E5.05c
    - type: ProteinComplexHasPartAssociation
      evidence: []
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-04-10'
        provided_by:
        - http://www.pombase.org
      term: PomBase:SPBC3H7.10
    - type: ProteinComplexHasPartAssociation
      evidence: []
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-06-15'
        provided_by:
        - http://www.pombase.org
      term: PomBase:SPCC895.06
    - type: ProteinComplexHasPartAssociation
      evidence: []
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-04-10'
        provided_by:
        - http://www.pombase.org
      term: PomBase:SPAC29A4.20
  molecular_function:
    type: MolecularFunctionAssociation
    term: GO:0106261
  part_of:
    type: BiologicalProcessAssociation
    evidence:
    - term: ECO:0000266
      reference: GO_REF:0000024
      with_objects:
      - UniProtKB:Q9H9T3
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-04-10'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-04-10'
      provided_by:
      - http://www.pombase.org
    term: GO:0002926
  molecular_associations:
  - type: MoleculeAssociation
    evidence: []
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-04-10'
      provided_by:
      - http://www.pombase.org
    predicate: RO:0002234
    molecule: gomodel:67e5e74400004366/67e5e74400004415
- id: gomodel:67e5e74400004366/67e5e74400004450
  enabled_by:
    type: EnabledByGeneProductAssociation
    evidence:
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN000299384
      - UniProtKB:Q9UI30
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-04-10'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-04-10'
      provided_by:
      - http://www.pombase.org
    term: PomBase:SPAC31A2.02
  molecular_function:
    type: MolecularFunctionAssociation
    term: GO:0141106
  occurs_in:
    type: CellularAnatomicalEntityAssociation
    evidence: []
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-04-10'
      provided_by:
      - http://www.pombase.org
    term: GO:0005829
  part_of:
    type: BiologicalProcessAssociation
    evidence:
    - term: ECO:0000266
      reference: GO_REF:0000024
      with_objects:
      - SGD:S000005329
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-04-10'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-04-10'
      provided_by:
      - http://www.pombase.org
    term: GO:0030488
  causal_associations:
  - type: CausalAssociation
    evidence:
    - term: ECO:0000318
      reference: GO_REF:0000033
      with_objects:
      - PANTHER:PTN000299384
      - UniProtKB:Q9UI30
      provenances:
      - contributor:
        - https://orcid.org/0000-0001-6330-7526
        date: '2025-04-10'
        provided_by:
        - http://www.pombase.org
    provenances:
    - contributor:
      - https://orcid.org/0000-0001-6330-7526
      date: '2025-04-10'
      provided_by:
      - http://www.pombase.org
    predicate: RO:0002629
    downstream_activity: gomodel:67e5e74400004366/67e5e74400004416
molecules:
- id: gomodel:67e5e74400004366/67e5e74400004415
  term: CHEBI:74882
- id: gomodel:67e5e74400004366/67e5e74400004384
  term: CHEBI:29179
- id: gomodel:67e5e74400004366/67e5e74400004396
  term: CHEBI:29182
- id: gomodel:67e5e74400004366/67e5e74400004385
  term: CHEBI:29179
- id: gomodel:67e5e74400004366/67e5e74400004423
  term: CHEBI:74851
- id: gomodel:67e5e74400004366/67e5e74400004383
  term: CHEBI:29169
- id: gomodel:67e5e74400004366/67e5e74400004386
  term: CHEBI:29169
- id: gomodel:67e5e74400004366/67e5e74400004395
  term: CHEBI:29177
objects:
- id: GO:0051392
  label: tRNA cytidine N4-acetyltransferase activity
  type: gocam:Object
- id: PomBase:SPAC20G8.09c
  label: nat10 Spom
  type: gocam:Object
- id: GO:0005730
  label: nucleolus
  type: gocam:Object
- id: ECO:0000318
  label: biological aspect of ancestor evidence used in manual assertion
  type: gocam:Object
- id: ECO:0007005
  label: high throughput direct assay evidence used in manual assertion
  type: gocam:Object
- id: GO:0180014
  label: protein-tRNA adaptor activity
  type: gocam:Object
- id: PomBase:SPBC25H2.10c
  label: tan1 Spom
  type: gocam:Object
- id: GO:0051391
  label: tRNA acetylation
  type: gocam:Object
- id: ECO:0000315
  label: mutant phenotype evidence used in manual assertion
  type: gocam:Object
- id: ECO:0000250
  label: sequence similarity evidence used in manual assertion
  type: gocam:Object
- id: CHEBI:29169
  label: tRNA(Leu)
  type: gocam:Object
- id: CHEBI:29179
  label: tRNA(Ser)
  type: gocam:Object
- id: GO:0008176
  label: tRNA (guanine(46)-N7)-methyltransferase activity
  type: gocam:Object
- id: PomBase:SPCPB16A4.04c
  label: trm8 Spom
  type: gocam:Object
- id: GO:0106004
  label: tRNA (guanine-N7)-methylation
  type: gocam:Object
- id: CHEBI:29177
  label: tRNA(Pro)
  type: gocam:Object
- id: CHEBI:29182
  label: tRNA(Tyr)
  type: gocam:Object
- id: GO:0003674
  label: molecular_function
  type: gocam:Object
- id: PomBase:SPCC18.13
  label: trm82 Spom
  type: gocam:Object
- id: ECO:0000307
  label: no evidence data found used in manual assertion
  type: gocam:Object
- id: ECO:0000266
  label: sequence orthology evidence used in manual assertion
  type: gocam:Object
- id: GO:0106261
  label: tRNA uridine(34) acetyltransferase activity
  type: gocam:Object
- id: GO:0033588
  label: elongator holoenzyme complex
  type: gocam:Object
- id: GO:0002926
  label: tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation
  type: gocam:Object
- id: PomBase:SPBC36.07
  label: elp1 Spom
  type: gocam:Object
- id: PomBase:SPAC29A4.20
  label: elp3 Spom
  type: gocam:Object
- id: PomBase:SPCC11E10.06c
  label: elp4 Spom
  type: gocam:Object
- id: PomBase:SPBC3H7.10
  label: elp6 Spom
  type: gocam:Object
- id: CHEBI:74882
  label: 5-(carboxymethyl)uridine 5'-monophosphate(2-) residue
  type: gocam:Object
- id: GO:0106335
  label: tRNA (5-carboxymethyluridine(34)-5-O)-methyltransferase activity
  type: gocam:Object
- id: PomBase:SPAC13D6.03c
  label: trm9 Spom
  type: gocam:Object
- id: GO:0002098
  label: tRNA wobble uridine modification
  type: gocam:Object
- id: CHEBI:74851
  label: 5-(2-methoxy-2-oxoethyl)uridine 5'-monophosphate residue(1-)
  type: gocam:Object
- id: GO:0141106
  label: tRNA methyltransferase activator activity
  type: gocam:Object
- id: PomBase:SPAC31A2.02
  label: trm112 Spom
  type: gocam:Object
- id: GO:0030488
  label: tRNA methylation
  type: gocam:Object
- id: GO:0005829
  label: cytosol
  type: gocam:Object
- id: GO:0005634
  label: nucleus
  type: gocam:Object
- id: ECO:0000305
  label: curator inference used in manual assertion
  type: gocam:Object
- id: PomBase:SPCC895.06
  label: elp2 Spom
  type: gocam:Object
- id: PomBase:SPBC18E5.05c
  label: elp5 Spom
  type: gocam:Object
provenances:
- contributor:
  - https://orcid.org/0000-0001-6330-7526
  date: '2025-10-25'
  provided_by:
  - http://www.pombase.org
