Reference - PMID:10491317 - Deletion of the sep1(+) forkhead transcription factor homologue is not lethal but causes hyphal growth in Schizosaccharomyces pombe.

Reference summary

PubMed ID

PMID:10491317

Title

Deletion of the sep1(+) forkhead transcription factor homologue is not lethal but causes hyphal growth in Schizosaccharomyces pombe.

Authors

Ribár B, Grallert A, Oláh E, Szállási Z

Citation

Biochem Biophys Res Commun 1999 Sep 24;263(2):465-74

Publication year

1999

Abstract

sep1(+), the Schizosaccharomyces pombe homologue of the forkhead/HNF-3 transcription factors, plays a role in the cell separation at the end of mitosis. Its inactivation by interruption of the coding region is not lethal but renders the sister cells unable to separate and causes hyphal growth. The persistence of unsplit septa indirectly interferes with the establishment of new cell polarity by preventing cell growth at cell tips. Temporal changes in the transcription of sep1(+) correlate with the cell cycle progression showing maximal expression at the peak of cell plate index in synchronized cultures. The constitutive overexpression of sep1(+) has no discernible effect on the morphology and physiology of the cells.

Annotation