Reference - PMID:11584278 - Proteins containing the UBA domain are able to bind to multi-ubiquitin chains.
Reference summary
- PubMed ID
- PMID:11584278
- Title
- Proteins containing the UBA domain are able to bind to multi-ubiquitin chains.
- Authors
- Wilkinson CR, Seeger M, Hartmann-Petersen R, Stone M, Wallace M, Semple C, Gordon C
- Citation
- Nat Cell Biol 2001 Oct;3(10):939-43
- Publication year
- 2001
- Abstract
- The UBA domain is a motif found in a variety of proteins, some of which are associated with the ubiquitin-proteasome system. We describe the isolation of a fission-yeast gene, mud1+, which encodes a UBA domain containing protein that is able to bind multi-ubiquitin chains. We show that the UBA domain is responsible for this activity. Two other proteins containing this motif, the fission-yeast homologues of Rad23 and Dsk2, are also shown to bind multi-ubiquitin chains via their UBA domains. These two proteins are implicated, along with the fission-yeast Pus1(S5a/Rpn10) subunit of the 26 S proteasome, in the recognition and turnover of substrates by this proteolytic complex.
