PomBase - Reference - PMID:11715016 - Mrc1 transduces signals of DNA replication stress to activate Rad53. - The Schizosaccharomyces pombe genome database

Reference summary

PubMed ID: PMID:11715016
Title: Mrc1 transduces signals of DNA replication stress to activate Rad53.
Authors: Alcasabas AA, Osborn AJ, Bachant J, Hu F, Werler PJ, Bousset K, Furuya K, Diffley JF, Carr AM, Elledge SJ
Citation: Nat Cell Biol 2001 Nov;3(11):958-65
Publication year: 2001
Abstract: Cells experiencing DNA replication stress activate a response pathway that delays entry into mitosis and promotes DNA repair and completion of DNA replication. The protein kinases ScRad53 and SpCds1 (in baker's and fission yeast, respectively) are central to this pathway. We describe a conserved protein Mrc1, mediator of the replication checkpoint, required for activation of ScRad53 and SpCds1 during replication stress. mrc1 mutants are sensitive to hydroxyurea and have a checkpoint defect similar to rad53 and cds1 mutants. Mrc1 may be the replicative counterpart of Rad9 and Crb2, which are required for activating ScRad53 and Chk1 in response to DNA damage.