Reference - PMID:12135745 - Cmk2, a novel serine/threonine kinase in fission yeast.

Reference summary

PubMed ID

PMID:12135745

Title

Cmk2, a novel serine/threonine kinase in fission yeast.

Authors

Alemany V, Sanchez-Piris M, Bachs O, Aligue R

Citation

FEBS Lett 2002 Jul 31;524(1-3):79-86

Publication year

2002

Abstract

The cmk2 gene of Schizosaccharomyces pombe encodes a 504 amino acid protein kinase with sequence homology with the calmodulin-dependent protein kinase family. The cmk2(+) gene is not essential for cell viability but overexpression of cmk2(+) blocks the cell cycle at G2 phase and this inhibition is cdc2-dependent. The Cmk2 is a cytoplasmic protein expressed in a cell cycle-dependent manner, peaking at the G1/S boundary. Overexpression of Cmk2 suppresses fission yeast DNA replication checkpoint defects but not DNA damage checkpoint defects, suggesting that the G2 cell cycle arrest mediated by high levels of Cmk2 provides sufficient time to correct DNA replication alterations.

Annotation