Reference - PMID:12615927 - Interaction of the anaphase-promoting complex/cyclosome and proteasome protein complexes with multiubiquitin chain-binding proteins.
Reference summary
- PubMed ID
- PMID:12615927
- Title
- Interaction of the anaphase-promoting complex/cyclosome and proteasome protein complexes with multiubiquitin chain-binding proteins.
- Authors
- Seeger M, Hartmann-Petersen R, Wilkinson CR, Wallace M, Samejima I, Taylor MS, Gordon C
- Citation
- J Biol Chem 2003 May 09;278(19):16791-6
- Publication year
- 2003
- Abstract
- Fission yeast Rhp23 and Pus1 represent two families of multiubiquitin chain-binding proteins that associate with the proteasome. We show that both proteins bind to different regions of the proteasome subunit Mts4. The binding site for Pus1 was mapped to a cluster of repetitive sequences also found in the proteasome subunit SpRpn2 and the anaphase-promoting complex/cyclosome (APC/C) subunit Cut4. The putative role of Pus1 as a factor involved in allocation of ubiquitinylated substrates for the proteasome is discussed.
