Reference - PMID:14511667 - A mutation in the gene involved in sister chromatid separation causes a defect in nuclear mRNA export in fission yeast.
Reference summary
- PubMed ID
- PMID:14511667
- Title
- A mutation in the gene involved in sister chromatid separation causes a defect in nuclear mRNA export in fission yeast.
- Authors
- Kalam Azad A, Ideue T, Ohshima Y, Tani T
- Citation
- Biochem Biophys Res Commun 2003 Oct 10;310(1):176-81
- Publication year
- 2003
- Abstract
- Fission yeast ptr4-1 is one of the mRNA transport mutants that accumulate poly(A)(+) RNA in the nuclei at the nonpermissive temperature. We cloned the ptr4(+) gene and found that it is identical with the cut1(+) gene essential for chromosome segregation during mitosis. ptr4/cut1 has no defects in nucleocytoplasmic transport of a protein, indicative of a specific blockage of mRNA export by this mutation. A mutant of Cut2p cooperating with Cut1p in sister chromatid separation also showed defective mRNA export at the nonpermissive temperature. Our results suggest a novel linkage between the cell division cycle and nuclear mRNA export in eukaryotic cells.
