Reference - PMID:14623292 - LAMMER kinase homolog, Lkh1, is involved in oxidative-stress response of fission yeast.
Reference summary
- PubMed ID
- PMID:14623292
- Title
- LAMMER kinase homolog, Lkh1, is involved in oxidative-stress response of fission yeast.
- Authors
- Park YD, Kang WH, Yang WS, Shin KS, Sook Bae K, Park HM
- Citation
- Biochem Biophys Res Commun 2003 Nov 28;311(4):1078-83
- Publication year
- 2003
- Abstract
- Previously, we reported that the LAMMER kinase homolog, Lkh1, is a negative regulator of filamentous growth and asexual flocculation in the fission yeast, Schizosaccharomyces pombe. Here, we report that the lkh1(+) null mutant is sensitive to oxidative stress because of a reduction in the expression of genes for antioxidant enzymes such as catalase (ctt1(+)) and Cu,Zn-superoxide dismutase (sod1(+)). Furthermore, the lkh1(+) null mutant shows increased levels of intracellular peroxides under conditions of oxidative stress compared with wild-type cells. Interestingly, expression of the gene for the transcription factor Atf1 is reduced in the lkh1(+) null mutant under oxidative stress, whereas expression of the transcription factor Pap1 is not. We report the novel finding that Lkh1 is involved in the oxidative-stress response of the fission yeast, S. pombe, and regulates the expression of antioxidant enzymes via the transcription factor Atf1.
