Reference - PMID:15297457 - On the slowing of S phase in response to DNA damage in fission yeast.
Reference summary
- PubMed ID
- PMID:15297457
- Title
- On the slowing of S phase in response to DNA damage in fission yeast.
- Authors
- Kumar S, Huberman JA
- Citation
- J Biol Chem 2004 Oct 15;279(42):43574-80
- Publication year
- 2004
- Abstract
- Eukaryotic cells slow their progression through S phase upon DNA damage. The mechanism that leads to this slowing is called the intra-S-phase checkpoint. Previous studies demonstrated that in the fission yeast Schizosaccharomyces pombe this checkpoint is mediated by a pathway that includes Rad3 (similar to human ATR and ATM) and Cds1 (similar to human Chk1 and Chk2). Here we present evidence that a major downstream target of this pathway is the cyclin-dependent kinase, Cdc2. We also present evidence suggesting that the intra-S-phase checkpoint makes a relatively minor contribution to the survival of cells with damaged DNA.
