Reference - PMID:15357289 - Schizosaccharomyces pombe rsm1 genetically interacts with spmex67, which is involved in mRNA export.
Reference summary
- PubMed ID
- PMID:15357289
- Title
- Schizosaccharomyces pombe rsm1 genetically interacts with spmex67, which is involved in mRNA export.
- Authors
- Yoon JH
- Citation
- J Microbiol 2004 Mar;42(1):32-6
- Publication year
- 2004
- Abstract
- We have previously isolated three synthetic lethal mutants from Schizosaccharomyces pombe in order to identify mutations in the genes that are functionally linked to spmex67 with respect to mRNA export. A novel rsm1 gene was isolated by complementation of the growth defect in one of the synthetic lethal mutants, SLMexl. The rsm1 gene contains no introns and encodes a 296 amino-acid-long protein with the RING finger domain, a C3HC4 in the N-terminal half. The deltarsm1 null mutant is viable, but it showed a slight poly(A)+ RNA accumulation in the nucleus. Also, the combination of deltarsm1 and deltaspmex67 mutations confers synthetic lethality that is accompanied by the severe poly(A)+ RNA export defect. These results suggest that rsm1 is involved in mRNA export from the nucleus.
