Reference - PMID:16357443 - A role for fission yeast Rab GTPase Ypt7p in sporulation.
Reference summary
- PubMed ID
- PMID:16357443
- Title
- A role for fission yeast Rab GTPase Ypt7p in sporulation.
- Authors
- Kashiwazaki J, Nakamura T, Iwaki T, Takegawa K, Shimoda C
- Citation
- Cell Struct Funct 2005;30(2):43-9
- Publication year
- 2005
- Abstract
- Ypt7p, a fission yeast (Schizosaccharomyces pombe) homologue of Rab7 GTPase, mediates fusion of endosomes to vacuoles and homotypic vacuole fusion. Here, we report that Ypt7p plays important roles in sporulation. Most ypt7Delta asci produced less than four spores, which were apparently immature and germinated at low frequency. Furthermore, ypt7Delta cells were defective in development of the forespore membranes. Vacuoles in sporulating cells were found to undergo extensive homotypic vacuole fusion to form a few large compartments occupying the entire cytoplasm of asci. This extensive vacuole fusion depended on Ypt7p.
